Download PDF
Thromb Haemost 2007; 98(04): 909-911
DOI: 10.1160/TH07-05-0341
Letters to the Editor
Schattauer GmbH

Factor VIIa/tissue factor-dependent gene regulation and pro-coagulant activity: Effect of factor VIIa concentration

Lars C. Petersen
Health Care Discovery, Novo Nordisk, Maaloev, Denmark
,
Tatjana Albrektsen
Health Care Discovery, Novo Nordisk, Maaloev, Denmark
,
Gertrud M. Hjortø
Health Care Discovery, Novo Nordisk, Maaloev, Denmark
,
Marianne Kjalke
Health Care Discovery, Novo Nordisk, Maaloev, Denmark
,
Søren E. Bjørn
Health Care Discovery, Novo Nordisk, Maaloev, Denmark
,
Brit B. Sørensen
Health Care Discovery, Novo Nordisk, Maaloev, Denmark
› Author Affiliations
Further Information

Publication History

Received 11 May 2007

Accepted after revision 22 June 2007

Publication Date:
01 December 2017 (online)

    Permissions and Reprints

 

 

  • References

  • 1 Belting M, Dorrell MI, Sandgren S. et al. Regulation of angiogenesis by tissue factor cytoplasmic domain signaling.. Nat Med 2004; 10: 502-509.
    CrossrefPubMedGoogle Scholar
  • 2 Rao LV. Tissue factor as a tumor procoagulant.. Cancer Metastasis Rev 1992; 11: 249-266.
    CrossrefPubMedGoogle Scholar
  • 3 Rickles FR, Shoji M, Abe K. The role of the hemostatic system in tumor growth, metastasis, and angiogenesis: tissue factor is a bifunctional molecule capable of inducing both fibrin deposition and angiogenesis in cancer.. Int J Hematol 2001; 73: 145-150.
    CrossrefPubMedGoogle Scholar
  • 4 Fernandez PM, Rickles FR. Tissue factor and angiogenesis in cancer.. Curr Opin Hematol 2002; 9: 401-406.
    CrossrefPubMedGoogle Scholar
  • 5 Thiruvikraman SV, Guha A, Roboz J. et al. In-situ localization of tissue factor in human atherosclerotic plaques by binding of digoxigenin-labeled factor-viia and factor-x.. Lab Inv 1996; 75: 451-461.
    PubMedGoogle Scholar
  • 6 Callander NS, Varki N, Rao LVM. Immunohistochemical identification of tissue factor in solid tumors.. Cancer 1992; 70: 1194-1201.
    CrossrefPubMedGoogle Scholar
  • 7 Kakkar AK, Lemoine NR, Scully MF. et al. Tissue factor expression correlates with histological grade in human pancreatic-cancer.. Br J Surg 1995; 82: 1101-1104.
    CrossrefPubMedGoogle Scholar
  • 8 Seto S, Onodera H, Kaido T. et al. Tissue factor expression in human colorectal carcinoma – Correlation with hepatic metastasis and impact on prognosis.. Cancer 2000; 88: 295-301.
    CrossrefPubMedGoogle Scholar
  • 9 Rottingen JA, Enden T, Camerer E. et al. Binding of human factor viia to tissue factor induces cytosolic ca2+ signals in j82 cells, transfected cos-1 cells, madin-darby canine kidney-cells and in human endothelialcells induced to synthesize tissue factor.. J Biol Chem 1995; 270: 4650-4660.
    CrossrefPubMedGoogle Scholar
  • 10 Camerer E, Rottingen JA, Iversen JG. et al. Coagulation factors VII and X induce Ca2+ oscillations in Madin-Darby canine kidney cells only when proteolytically active.. J Biol Chem 1996; 271: 29034-29042.
    CrossrefPubMedGoogle Scholar
  • 11 Poulsen LK, Jacobsen N, Sorensen BB. et al. Signal transduction via the mitogen-activated protein kinase pathway induced by binding of coagulation factor VIIa to tissue factor.. J Biol Chem 1998; 273: 6228-6232.
    CrossrefPubMedGoogle Scholar
  • 12 Sorensen BB, Freskgard PO, Nielsen LS. et al. Factor VIIa-induced p44/42 mitogen-activated protein kinase activation requires the proteolytic activity of factor VIIa and is independent of the tissue factor cytoplasmic domain.. J Biol Chem 1999; 274: 21349-21354.
    CrossrefPubMedGoogle Scholar
  • 13 Versteeg HH, Hoedemaeker I, Diks SH. et al. Factor VIIa/tissue factor-induced signaling via activation of Src-like kinases, phosphatidylinositol 3-kinase, and Rac.. J Biol Chem 2000; 275: 28750-28756.
    CrossrefPubMedGoogle Scholar
  • 14 Versteeg HH, Sorensen BB, Slofstra SH. et al. VIIa/ tissue factor interaction results in a tissue factor cytoplasmic domain-independent activation of protein synthesis, p70, and p90 S6 kinase phosphorylation.. J Biol Chem 2002; 277: 27065-27072.
    CrossrefPubMedGoogle Scholar
  • 15 Pendurthi UR, Allen KE, Ezban M. et al. Factor VIIa and thrombin induce the expression of Cyr61 and connective tissue growth factor, extracellular matrix signaling proteins that could act as possible downstream mediators in factor VIIa center dot tissue factor-induced signal transduction.. J Biol Chem 2000; 275: 14632-14641.
    CrossrefPubMedGoogle Scholar
  • 16 Camerer E, Rottingen JA, Gjernes E. et al. Coagulation factors VIIa and Xa induce cell signaling leading to up-regulation of the egr-1 gene.. J Biol Chem 1999; 274: 32225-32233.
    CrossrefPubMedGoogle Scholar
  • 17 Pendurthi UR, Allen KE, Ezban M. et al. Factor VIIa and thrombin induce the expression of Cyr61 and connective tissue growth factor, extracellular matrix signaling proteins that could act as possible downstream mediators in factor VIIa x tissue factor-induced signal transduction.. J Biol Chem 2000; 275: 14632-14641.
    CrossrefPubMedGoogle Scholar
  • 18 Wang X, Gjernes E, Prydz H. Factor VIIa induces tissue factor-dependent up-regulation of interleukin-8 in a human keratinocyte line.. J Biol Chem 2002; 277: 23620-23626.
    CrossrefPubMedGoogle Scholar
  • 19 Rao LVM, Pendurthi UR. Tissue factor-factor VIIa signaling.. Arterioscler Thromb Vasc Biol 2005; 25: 47-56.
    PubMedGoogle Scholar
  • 20 Fair DS, MacDonald MJ. Cooperative interaction between factor VII and cell surface-expressed tissue factor.. J Biol Chem 1987; 262: 11692-11698.
    PubMedGoogle Scholar
  • 21 Le DT, Rapaport SI, Rao LVM. Relations between factor VIIa binding and expression of factor VIIa-tissue factor catalytic activity on cell surfaces.. J Biol Chem 1992; 267: 15447-15454.
    PubMedGoogle Scholar
  • 22 Rao LVM, Pendurthi UR. Tissue factor on cells.. Blood Coagul Fibrinol 1998; 9: S27-S35.
    PubMedGoogle Scholar
  • 23 Sorensen BB, Persson E, Freskgard PO. et al. Incorporation of an active-site inhibitor in factor VIIa alters the affinity for tissue factor.. J Biol Chem 1997; 272: 11863-11868.
    CrossrefPubMedGoogle Scholar
  • 24 Rao LVM, Pendurthi UR. Tissue factor-factor VIIa signaling.. Arterioscler Thromb Vasc Biol 2005; 25: 47-56.
    PubMedGoogle Scholar
  • 25 Ahamed J, Versteeg HH, Kerver M. et al. Disulfide isomerization switches tissue factor from coagulation to cell signaling.. PNAS 2006; 103: 13932-13937.
    CrossrefPubMedGoogle Scholar
  • 26 Albrektsen T, Sorensen BB, Hjortoe GM. et al. Transcriptional program induced by factor VIIa-tissue factor, PAR1 and PAR2 in MDA-MB-231 cells.. J Thromb Haemost 2007; 5: 1588-1597.
    CrossrefPubMedGoogle Scholar
  • 27 Jiang X, Bailly MA, Panetti TS. et al. Formation of tissue factor-factor VIIa-factor Xa complex promotes cellular signaling and migration of human breast cancer cells.. J Thromb Haemost 2004; 2: 93-101.
    CrossrefPubMedGoogle Scholar
  • 28 Hjortoe GM, Petersen LC, Albrektsen T. et al. Tissue factor-factor VIIa-specific up-regulation of IL-8 expression in MDA-MB-231 cells is mediated by PAR-2 and results in increased cell migration.. Blood 2004; 103: 3029-3037.
    CrossrefPubMedGoogle Scholar
  • 29 Zhou JN, Stenlinder M, Linder S. Tissue factor messenger-rna expression in breast-carcinoma cells.. Oncol Rep 1996; 3: 443-445.
    PubMedGoogle Scholar
  • 30 Kjalke M, Oliver JA, Monroe DM. et al. The effect of active site-inhibited factor viia on tissue factor-initiated coagulation using platelets before and after aspirin administration.. Thromb Haemost 1997; 78: 1202-1208.
    Article in Thieme ConnectPubMedGoogle Scholar
  • 31 Bouchard BA, Shatos MA, Tracy PB. Human brain pericytes differentially regulate expression of procoagulant enzyme complexes comprising the extrinsic pathway of blood-coagulation.. Arterioscler Thromb Vasc Biol 1997; 17: 1-9.
    CrossrefPubMedGoogle Scholar
  • 32 Wolberg AS, Monroe DM, Roberts HR. et al. Tissue factor de-encryption: ionophore treatment induces changes in tissue factor activity by phosphatidylserinedependent and -independent mechanisms.. Blood Coagul Fibrinolysis 1999; 10: 201-210.
    CrossrefPubMedGoogle Scholar
  • 33 Rizoli SB, Chughtai T. The emerging role of recombinant activated Factor VII (rFVIIa) in the treatment of blunt traumatic haemorrhage.. Expert Opin Biol Ther 2006; 6: 73-81.
    CrossrefPubMedGoogle Scholar
  • 34 Mathew P. The use of rFVIIa in non-haemophilia bleeding conditions in paediatrics – A systematic review.. Thromb Haemost 2004; 92: 738-746.
    Article in Thieme ConnectPubMedGoogle Scholar
  • 35 Monroe DM, Hoffman M, Oliver JA. et al. Platelet activity of high-dose factor VIIa is independent of tissue factor.. Br J Haematol 1997; 99: 542-527.
    CrossrefPubMedGoogle Scholar
  • 36 Lisman T, De-Groot PG. Mechanism of action of recombinant factor VIIa.. J Thromb Haemost 2003; 1: 1138-1139.
    CrossrefPubMedGoogle Scholar
  • 37 Butenas S, Brummel KE, Bouchard BA. et al. How factor VIIa works in hemophilia.. J Thromb Haemost 2003; 1: 1158-1160.
    CrossrefPubMedGoogle Scholar
  • 38 Livnat T, Zivelin A, Martinowitz U. et al. Prerequisites for recombinant factor VIIa-induced thrombin generation in plasmas deficient in factors VIII, IX or XI.. J Thromb Haemost 2006; 4: 192-200.
    PubMedGoogle Scholar
  • 39 Polgar J, Matuskova J, Wagner DD. The P-selectin, tissue factor, coagulation triad.. J Thromb Haemost 2005; 3: 1590-1596.
    CrossrefPubMedGoogle Scholar
  • 40 Gando S. Tissue factor in trauma and organ dysfunction.. Semin Thromb Hemost 2006; 32: 48-53.
    Article in Thieme ConnectPubMedGoogle Scholar
  • 41 Morrissey JH, Macik BG, Neuenschwander PF. et al. Quantitation of activated factor VII levels in plasma using a tissue factor mutant selectively deficient in promoting factor VII activation.. Blood 1993; 81: 734-744.
    PubMedGoogle Scholar
  • 42 Rao LV, Rapaport SI. Activation of factor VII bound to tissue factor: a key early step in the tissue factor pathway of blood coagulation.. Proc Natl Acad Sci USA 1988; 85: 6687-6691.
    CrossrefPubMedGoogle Scholar
  • 43 Rao LVM, Williams T, Rapaport SI. Studies of the activation of factor VII bound to tissue factor.. Blood 1996; 87: 3738-3748.
    PubMedGoogle Scholar