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DOI: 10.1160/TH04-03-0163
The use of rFVIIa in non-haemophilia bleeding conditions in paediatrics
A systematic reviewPublication History
Received
15 March 2004
Accepted after resubmission
04 June 2004
Publication Date:
06 December 2017 (online)
![](https://www.thieme-connect.de/media/10.1055-s-00035024/200404/lookinside/thumbnails/10-1160-th04-03-0163-1.jpg)
Summary
From its original envisioned use in patients with hemophilia and inhibitors, recombinant factor VIIa has been increasingly used in a variety of non-hemophilia bleeding/hemorrhagic situations with great efficacy. Most of the reported work has been in adult patients. This paper sets out to review its use in the pediatric non-hemophilia patients and the varied conditions it has been tried and used. Most of the published literature has shown that this agent is efficacious, safe and can be used as an adjunctive measure in the achievement of hemostasis. However, most of the published work is mainly anecdotal, case reports or small series. Randomized trials in children are eagerly awaited.
* On behalf of the Scientific and Standardization Committee on Perinatal/Pediatric Hemostasis, ISTH. Presented in part at the SSC committee meeting, ISTH, Birmingham 2003.
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