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Thromb Haemost 2004; 91(06): 1129-1136
DOI: 10.1160/TH03-12-0778
Blood Coagulation, Fibrinolysis and Cellular Haemostasis
Schattauer GmbH

Levels of annexin IV and V in the plasma of pregnant and postpartum women

Junko Masuda
1   Graduate School of Humanities and Sciences, Ochanomizu University, Tokyo, Japan
,
Eiji Takayama
3   Parasitology, National Defense Medical College, Saitama, Japan
,
Ayano Satoh
1   Graduate School of Humanities and Sciences, Ochanomizu University, Tokyo, Japan
,
Michiru Ida
1   Graduate School of Humanities and Sciences, Ochanomizu University, Tokyo, Japan
,
Tadashi Shinohara
4   Internal Medicine I, National Defense Medical College, Saitama, Japan
,
Kyoko Kojima-Aikawa
2   Department of Chemistry, Ochanomizu University, Tokyo, Japan
,
Fumitaka Ohsuzu
4   Internal Medicine I, National Defense Medical College, Saitama, Japan
,
Kuniaki Nakanishi
5   Pathology I, National Defense Medical College, Saitama, Japan
,
Koichi Kuroda
6   Obstetrics and Gynecology, National Defense Medical College, Saitama, Japan
,
Mitsutaka Murakami
7   Japan Self Defense Force Sendai Hospital, Sendai, Japan
,
Kimihiro Suzuki
4   Internal Medicine I, National Defense Medical College, Saitama, Japan
,
Isamu Matsumoto
2   Department of Chemistry, Ochanomizu University, Tokyo, Japan
› Author Affiliations
Further Information

Publication History

Received 21 December 2003

Accepted after revision 01 March 2003

Publication Date:
02 December 2017 (online)

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Summary

Annexin (Anx) V is pivotal in the maintenance of pregnancy by preventing the activation of blood coagulation. The homology of the amino acid sequence between Anx IV and Anx V is highest in Anx family proteins. However, little is known about the roles of Anx IV in pregnancy.The aim of this study is to clarify the roles of circulating Anx IV and Anx V in normal pregnancy. Subjects were non-pregnant women (n = 50), 120 pregnant women, and maternal subjects just after delivery (n = 53) or postpartum (n = 67). Anx IV in the plasma of non-pregnant women was at a concentration 20 times that of Anx V. The plasma levels of Anx IV suddenly increase after delivery, but Anx V levels remain low during this period. Anx IV and Anx V exert similar levels of anticoagulant activity. Anx IV protein was expressed on the basal surface of syncytiotrophoblasts; Anx V protein, on the apical surface of syncytiotrophoblasts. These results suggest that Anx IV enters the maternal bloodstream just after delivery and might play a role in preventing disseminated intravascular coagulopathy, and that Anx V helps to prevent clotting in the placenta during pregnancy.

Keywords

Disseminated intravascular coagulopathy (DIC) - pregnancy - annexin - anticoagulant
 

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