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Thromb Haemost 2004; 91(06): 1097-1104
DOI: 10.1160/TH03-12-0773
Blood Coagulation, Fibrinolysis and Cellular Haemostasis
Schattauer GmbH

The effects of long-term diet and omega-3 fatty acid supplementation on coagulation factor VII and serum phospholipids with special emphasis on the R353Q polymorphism of the FVII gene

Anja S. Lindman
1   The University College of Akershus, Lillestrøm, Norway
2   Institute for Nutrition Research, University of Oslo, Oslo, Norway
,
Jan I. Pedersen
2   Institute for Nutrition Research, University of Oslo, Oslo, Norway
,
Elsa M. Hjerkinn
3   Center for Clinical Research, Ullevål University Hospital, Oslo, Norway
,
Harald Arnesen
3   Center for Clinical Research, Ullevål University Hospital, Oslo, Norway
,
Marit B. Veierød
2   Institute for Nutrition Research, University of Oslo, Oslo, Norway
4   Section of Medical Statistics, University of Oslo, Oslo, Norway
,
Ingrid Ellingsen
5   Dept. of Preventive Cardiology, Ullevål University Hospital, Oslo, Norway
,
Ingebjørg Seljeflot
3   Center for Clinical Research, Ullevål University Hospital, Oslo, Norway
› Author AffiliationsFinancial support: This work was supported by grants from the Throne-Holst’s Foundation for Nutrition Research, The Norwegian Health Association, and the Norwegian Retail Company RIMI for the DOIT study.
Further Information

Publication History

Received 19 December 2003

Accepted after resubmission 29 March 2004

Publication Date:
02 December 2017 (online)

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Summary

The aim of the present study was to investigate the effect of long-term diet and very long chain n-3 fatty acids (VLC n-3) intervention on plasma coagulation factor VII (FVII), cholinecontaining phospholipids (PC) and triglycerides (TG), especially related to the R353Q polymorphism of the FVII gene. The present investigation included 219 subjects from the Diet and Omega-3 Intervention Trial on atherosclerosis (DOIT), a 2x2 factorial designed study in elderly men with long-standing hypercholesterolemia. The subjects were randomly allocated to receive placebo capsules (corn oil) (control), placebo capsules and dietary advice (“Mediterranean type” diet), VLC n-3 capsules, or VLC n-3 capsules and dietary advice combined. The R353Q genotype and the levels of FVIIc, FVIIag, FVIIa, PC, and TG at baseline and after 6 months were determined. Diet interention was followed by a significant reduction of 5.1% in the levels of FVIIag and 2.4 mU/ml in FVIIa (95% CI −7.4, −2.9, and −3.8, −1.1, respectively) (both p<0.001) compared to the no diet group, independent of genotype. No effects of diet intervention on FVIIc, PC or TG were observed. After VLC n-3 supplementation the TG levels were significantly reduced compared to placebo (p=0.01), whereas all FVII levels and PC remained unchanged. Dietary advice towards a “Mediterranean type” diet, but not VLC n-3 supplementation, was shown to reduce the levels of FVIIag and FVIIa after 6 months, independent of genotype. The results indicate the dietary advice to be more favourable in reducing this risk factor for CVD as compared to specific VLC n-3 supplementation.

Keywords

Coagulation factor VII - R353Q - diet - omega-3 fatty acids - phospholipids
 

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