Hepatotoxic Side-Effect of Clomethiazole

F. Heinemann; H. J. Assion

doi:10.1055/s-2007-979571

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Pharmacopsychiatry 1996; 29(5): 196-197
DOI: 10.1055/s-2007-979571

Case Report

Hepatotoxic Side-Effect of Clomethiazole

F. Heinemann¹ , H.J. Assion²

¹Department of Neurology, St.-Josef-Hospital, Moers, Germany
²Department of Psychiatry, University Medical College, Bonn, Germany

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Publication Date:
23 April 2007 (online)

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We report on a patient with a history of alcoholism who developed hyperbilirubinemia induced by treatment with clomethiazole during two hospitalizations. After discontinuation of clomethiazole symptoms of cholostasis improved. Clomethiazole is a thiazole analogon and is chemically related to thiamine (vitamine B1). It can be administered as tablets, capsules, mixtures, and a 0.8 % solution. Because of its sedative, hypnotic, and anticonvulsive effects it is used in the treatment of alcoholic delirium.