A Chiral Tridentate Schiff Base Catalyst for Alkylzinc Addition to Aldehydes

Significance

In the field of enantioselective addition of alkylzinc reagents to aldehydes, most of the ligands developed to date are bidentate and only a few examples of tridentate ligands (see review below) have been reported. Hayashi et al. describe a new chiral tridentate Schiff base catalyst that compares favorably to previous systems and has broader substrate scope.