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Synfacts 2006(11): 1190-1190  
DOI: 10.1055/s-2006-949407
Polymer-Supported Synthesis
© Georg Thieme Verlag Stuttgart · New York

Self-Supported Noyori-Type Catalysts Using Achiral Bridged-BIPHEPs

Contributor(s): Yasuhiro Uozumi, Yohei Oe
Y. Liang, Z. Wang, K. Ding
Shanghai Institute of Organic Chemistry, P. R. of China
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Publication History

Publication Date:
24 October 2006 (online)

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Significance

Achiral bridged-BIPHEPs 1 reacted with [(C6H6)RuCl2]2 in DMF followed by treatment with bridged-DPEN 2 to give the self-supported catalysts 3 in almost quantitative yield (eq. 1). Aromatic ketones 4a-f were hydrogenated in the presence of self-supported catalyst 3b to give the corresponding alcohols 5a-f quantitatively with 71.9-86.9% ee (eq. 2). Catalyst 3b can be reused four times without significant loss of catalytic activity and enantioselectivity.