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Synfacts 2006(11): 1083-1083  
DOI: 10.1055/s-2006-949387
Synthesis of Natural Products and Potential Drugs
© Georg Thieme Verlag Stuttgart · New York

Synthesis of (-)-Pironetin

Contributor(s): Philip Kocienski, John Cooksey
X. Shen, A. S. Wasmuth, J. Zhao, C. Zhu, S. G. Nelson*
University of Pittsburgh, USA
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Publication History

Publication Date:
24 October 2006 (online)

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Significance

(-)-Pironetin is isolated from Streptomyces sp NK10958 and exhibits potent anti-­tumor activity. The Nelson group uses the synthesis of (-)-pironetin to demonstrate the use of their iterative, alkaloid-catalyzed acyl halide-aldehyde cyclocondensation (AAC) reaction to prepare propionate subunits in a stereocontrolled manner.