Body Weight Gain after Administration
of Antipsychotic Drugs

Letter to the Editor

In our article: Body Weight Gain after Administration of Antipsychotic Drugs: Correlation with Leptin, Insulin and Reproductive Hormones, by Baptista et al., Pharmacopsychiatry, 2000; 33: 81 - 88, we reported a negative significant correlation between the “change in glucose levels and the change in leptin levels” in healthy men who significantly gained weight during treatment with sulpiride for 1 month (Fig. 2).

We interpreted that finding as an indirect support for an inverse correlation between leptin and insulin sensitivity. That interpretation may be wrong. Since insulin levels significantly increased after SUL administration (Table 2), we can not properly deduct the pattern on insulin sensitivity in our subjects.

Future studies must consider the direct assessment of insulin sensitivity in patients treated with neuroleptics and its correlation with serum leptin levels