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Synfacts 2011(12): 1335-1335
DOI: 10.1055/s-0031-1289367
DOI: 10.1055/s-0031-1289367
Metal-Catalyzed Asymmetric Synthesis and Stereoselective Reactions
© Georg Thieme Verlag
Stuttgart ˙ New York
Stereoselective Rhodium-Catalyzed Amination of Alkenes
H. Lebel*, C. Spitz, O. Leogane, C. Trudel, M. Parmentier
Université de Montréal, Canada
Further Information
Publication History
Publication Date:
18 November 2011 (online)
Significance
The current work describes a rhodium-catalyzed intermolecular aziridination and C-H amination of alkenes to produce chiral carbamate-protected aziridines and allylic amines. The products can be isolated in good yields and diastereoselectivities employing a readily available chiral N-tosyloxycarbamate. The general reaction scale for this transformation is 0.25 mmol.