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Synfacts 2011(12): 1342-1342
DOI: 10.1055/s-0031-1289361
DOI: 10.1055/s-0031-1289361
Metal-Catalyzed Asymmetric Synthesis and Stereoselective Reactions
© Georg Thieme Verlag
Stuttgart ˙ New York
Stereocontrol of the Combined C-H Functionalization/Cope Rearrangement
Y. Lian, K. I. Hardcastle, H. M. L. Davies*
Emory University, Atlanta, USA
Further Information
Publication History
Publication Date:
18 November 2011 (online)
Significance
The authors report on a highly stereoselective C-H functionalization/Cope rearrangement. New substrates were designed leading to the formation of products with the opposite diastereoselectivity to that previously obtained. The general reaction scale for this transformation is 1.0 mmol.