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Synfacts 2011(12): 1352-1352  
DOI: 10.1055/s-0031-1289348
Metal-Mediated Synthesis
© Georg Thieme Verlag Stuttgart ˙ New York

Cu-Mediated Cyanation of Aryl Halides

Contributor(s): Paul Knochel, Andreas K. Steib
G. Zhang, X. Ren, J. Chen, M. Hu*, J. Cheng*
Wenzhou University, P. R. of China
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Publication History

Publication Date:
18 November 2011 (online)

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Significance

A new preparation of aryl nitriles from aryl halides is described. This reaction is mediated by copper and the source of cyanide is a combination of N,N-dimethylformamide and NH4HCO3. Electron-rich aryl halides give slightly higher yields than those possessing electron-withdrawing groups.