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Synfacts 2011(10): 1099-1099  
DOI: 10.1055/s-0030-1261056
Metal-Catalyzed Asymmetric Synthesis and Stereoselective Reactions
© Georg Thieme Verlag Stuttgart ˙ New York

Dysprosium(III) Triflate Catalyzed Aza-Piancatelli Rearrangement

Contributor(s): Hisashi Yamamoto, Patrick Brady
L. I. Palmer, J. Read de Alaniz*
University of California, Santa Barbara, USA
Further Information

Publication History

Publication Date:
20 September 2011 (online)

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Dysprosium(III) Triflate Catalyzed Aza-Piancatelli RearrangementSynfacts 2011; 2011(11): 1264-1264
DOI: 10.1055/s-0031-1289300

Significance

This Lewis acid catalyzed process generates aza-spirocyclic compounds with high efficiency. Importantly, a wide variety of functional groups are tolerated, and both 5,5- and 5,6-fused ring systems can be synthesized. These products are of interest due to their potential biological activities.