One-Pot Modified Japp-Klingeman-Fischer Indole Synthesis

Significance

Reported is the synthesis of substituted indoles through a one-pot, two-step combination of a modified Japp-Klingeman reaction and a Fischer indole synthesis. The variation of the Japp-Klingeman reaction shown above is most significant, because it does not involve purification of the intermediates and was reported by the same group some time ago in relation to the formation of α-hydrazono esters. The extension of this work to ultimately give indoles was conducted systematically and was well reported.