DOI: 10.1055/s-00000131

Synfacts

Issue 11 · Volume 19 · November 2023 DOI: 10.1055/s-013-58446

Synform

A181
SYNFORM ISSUE 2023/11

Synthesis of Natural Products

z1065
All PDFs of this category
1065
Total Synthesis of (±)-iso-Phomopsene
1066
Syntheses of Illicium Sesquiterpenes
1067
Total Synthesis of (–)-Cephalotine A
1068
Synthesis of (±)-Discorhabdin B
1069
Syntheses of Eburnane Alkaloids
1070
Total Synthesis of (±)-Metaphanine
1071
Synthesis of (±)-Hypnophilin

Synthesis of Heterocycles

z1073
All PDFs of this category
1073
Ring-Expansion Skeletal Editing of Cycloalkanols through Metal-Free Nitrogen Insertion
1074
Synthesis and Reactivity of a Conformationally Rigid Cubane-Derived Amino Acid
1075
Predictable, Scalable Aliphatic C–H Oxidation of Complex, Drug-Like Molecules
1076
On-DNA Synthesis of Spirocyclic Azetidines via Photocatalyzed [2+2] Cycloaddition
1077
[2+2]-Cycloaddition Approach to Monocyclic Azetidines
1078
P(III)-Directed C(sp2)–H Activation for the Synthesis of Dihydroquinolinones
1079
Synthesis of 3‑Fluoropyrazoles via Radical-Polar Crossover Photoinduced Cyclization
1080
Metal-Free Multicomponent Annulation Cascade for the Synthesis of Pyrimidines
1081
Aza-Bicyclobutanes as Astonishingly Efficient Coupling Partners for Nickel Catalysis
1082
General Approach to Cyclic Arylsulfoximines and their Derivatives
1083
Asymmetric Baeyer–Villiger Oxidation to Access Tetronic Acids
1084
Multigram Access to Functionalized Isoxazolines

Synthesis of Materials and Unnatural Products

z1085
All PDFs of this category
1085
Living Polymerization of Length-Controlled GNR
1086
One-Pot Multicomponent Synthesis of Quinolines
1087
Mechanical Force-Induced Conformational Flips
1088
Highly Crowded Triply Fused Carbo[7]-helicene
1089
Azacoronene with Faraday Rotation
1090
Mild Polychlorination for Arenes
1091
Capturing Persistent Radical
1092
Tetracyanodiimide with High Electron Mobility
1093
Dianionic Diindenodibenzoanthracene
1094
Quinazoline from ortho-Lithiation of Fluorobenzene
1095
Superacid and Superbase from a Constrained Boron
1096
Phenanthrene from Tandem Catellani and retro-Diels–Alder Reactions

Metals in Synthesis

z1097
All PDFs of this category
1097
Making Acyl Fluorides by Synergistic Palladium/Phosphine-Catalyzed Fluorocarbonylation
1098
Skeletal Editing of Arenes through Intramolecular Nitrogen Atom Insertion under Rhodium Catalysis
1099
Al-Salen Photocatalyzed Deracemization of Cyclopropanes
1100
Enantioselective Heteroarylcyanation of Styrenes under Photoelectrochemical Asymmetric Catalysis
1101
Asymmetric Cyanofunctionalization of Alkenes by Dual Copper and Photoredox Catalysis
1102
Enantiodivergent Copper-Catalyzed Syntheses of β,γ-Unsaturated Ketones from 1,3-Butadienyl Silanes
1103
Three-Component Pd-Catalyzed N-Acylation of Amino Acid Esters Using Mo(CO)6 as a CO Surrogate
1104
Nickel-Catalyzed Arylation of Propargyl Acetates with Arylboronic Acids via Meyer–Schuster-type Migration
1105
Cobalt-Catalyzed Wagner–Meerwein Hydrofluorination of gem-Disubstituted Allylarenes
1106
Nickel-Catalyzed Borylative Coupling: An Access to Functionalized Chiral Homoallylic Alcohols
1107
Visible-Light-Induced Palladium-Catalyzed Homologative Amination of Styrenes
1108
Synthesis of Sulfonamides Using Synergetic Photoredox and Copper Catalysis
1109
Advancing the Mechanistic Understanding of Ni-Catalyzed Hydrocyanation
1110
Asymmetric Electrochemical Cross-Dehydrogenative Amination Under Nickel Catalysis
1111
Radical Cyclization of Biaryl Enones Using Blue LEDs: An Access to Functionalized Phenanthrone Derivatives
1112
Chromium-Catalyzed Three-Component Cross-Coupling to Access Diarylated Tertiary Alkanes
1113
Asymmetric Pd-Catalyzed Allylation of N-Functionalized Glycine Ethyl Esters
1114
Pd(II)-Catalyzed C(sp3)–H Activation/Spirocyclization of Alkyl Amides
1115
A Cationic Palladium Terphenyl Phosphine Catalyst Enables Broad-Scope Amination of Aryl Sulfamates
1116
Iron-Catalyzed Synthesis of 2,5-dicarbonyl-3-ene-phosphates via Furan Ring Opening
1117
Palladium-Catalyzed Synthesis of β-Fluorinated Amines
1118
NiH-Catalyzed Asymmetric Migratory Hydroalkylation of Cycloalkenes to 1,2-cis-Disubstituted Cyclohexanes
1119
Ir-Catalyzed Asymmetric Hydrogenation/Alkylation Cascade of Pyridines Towards N-Heterocycles
1120
Asymmetric Hydrophosphination of Cyclopropenes
1121
Solvent-Mediated Regioselectivity in the Rh-Catalyzed Arylation of 1-Bromo-2,2-difluoroethylene
1122
Merging Visible Light-Induced Palladium-Catalyzed Desaturation and Tsuji–Trost-Type Allylic Sulfonation
1123
Development of Chiral Gold and Platinum Complexes for Enantioselective Alkoxycyclization of Enynes

Polymer-Supported Synthesis

z1125
All PDFs of this category
1125
Nucleophilic C-Alkylation of Phenols with Alcohols Promoted by Anatase TiO2
1126
Silylation of Electron-Deficient Olefins Catalyzed by a Copper on Chitosan/Cellulose Composite
1127
Reductive Amidation of Nitro Compounds with Esters Catalyzed by Nickel Supported on TiO2
1128
Tandem Hydroboration/Photooxidation of Terminal Alkenes and Alkynes with a Cu MOF Catalyst
1129
C–O Coupling of Aryl Halides with Phenols by a Copper Catalyst Immobilized on Fe3O4 Nanoparticles
1130
EDOT-Incorporated Covalent Organic Polymers for Photocatalytic Organic Transformations
1131
Synthesis of Imidazobenzothiadiazoles Catalyzed by Fluorescein in Metal-Organic Frameworks
1132
Transfer Hydrogenation of Azoarenes and Nitroarenes Using Co, Supported on N-Doped Porous Carbon
1133
Asymmetric α-Alkylation of Aldehydes Photocatalyzed by a Chiral Covalent Organic Framework
1134
Magnetic Ni/Cu Alloy Nanoparticles for Sonogashira and C–N Cross-Coupling Reactions
1135
A Nickel-Incorporated Covalent Organic Framework for Photocatalytic C–X Bond Forming Reactions
1136
Selective Hydrogenation of Diarylalkynes and α,β-Unsaturated Carbonyls Using NiII Supported on MOF

Organo- and Biocatalysis

z1137
All PDFs of this category
1137
Ketone Chain-Walking Isomerization by Organocatalysis
1138
Stereoselective Synthesis of Cyclopropane Derivatives from Mixtures of (E)- and (Z)-Enol Acetates
1139
Lewis Acid-Catalyzed C–F Bond Activation and Functionalization
1140
NHC-Catalyzed Ionic Alkylation of Aldehydes with Unactivated Halides
1141
Asymmetric [2+2] Photocycloaddition to Truxinates by Brønsted Acid-Catalyzed Chromophore Activation
1142
Stereoselective Synthesis of Noncanonical Amino Acids Enabled by Photoredox-Pyridoxal Radical Biocatalysis
1143
Isoquinoline-Forming Staudinger–aza-Wittig Reaction Enabled by Atroposelective PIII/PIV=O Redox Catalysis
1144
Organocatalytic Friedel–Crafts Reaction of Unactivated Arenes
1145
Spiro Phosphoric Acid-Catalyzed Amination Reaction of In Situ-Generated Ketenes Toward α-Chiral Amides

Innovative Drug Discovery and Development

z1147
All PDFs of this category
1147
Target Mutant KRAS with Molecular Glue
1148
Mild Synthesis of 4-Quinolones
1149
Transition Metal-Free Net Heterobenzylic Coupling
1150
Bioorthogonal Chemistry with Azomethine Imines and Isonitriles
1151
Discovery of SMD-3040 as a Potent and Selective Degrader for the Synthetic Lethality Target, SMARCA2
1152
PCNA Inhibitor Exploits Cancer-Selective Vulnerability to Suppress Tumor Growth
1153
General Methylenecyclobutane Synthesis Enabled by Copper-Catalyzed Borylative Cyclization
1154
Novel OGA PET Tracer with Improved Properties and Potential for Translation to Clinical Application
1155
Equilibration of [11C,14C]CO2 and CO2 Radical Anion Enables New Approach to Carbon Isotope Radiolabeling
1156
Indazole-Phenol Bioisosterism in NMDA GluN2B Receptor Antagonists with Metabolic Advantage
1157
α-Difluoroalkylation of Benzyl Amines with Trifluoromethylarenes
1158
Synthesis of a Mitochondria-Targeted Photoactivable Melatonin Ligand
1159
Synthesis of π-Extended Coumarins Using δ-Acetoxy Allenoate as a 5C-Synthon

Peptide Chemistry

z1161
All PDFs of this category
1161
Cu-Catalyzed Regioselective Chlorination of Peptides
1162
Asymmetric Synthesis of Polysubstituted Chiral Proline Esters from Azomethine Ylides and 1,3-Enynes
1163
Photoinduced Pd-Catalyzed Synthesis of Chiral Piperidine 2-Carboxyamides
1164
α-Benzylation of N-Aryl Amino Acids
1165
Thiopeptide Synthesis Using Nitroalkanes
1166
Asymmetric α-Allylation for the Synthesis of α,α-Disubstituted Amino Acids with Vicinal Chiral Centers
1167
Catalytic Asymmetric α-Allylation of N-Unprotected Amino Esters
1168
Metal-Free C2 Alkylation of Tryptophan and Tryptophan-Containing Peptides
1169
Organocatalyzed Enantioselective Synthesis of α-Amino Acids

Flow Chemistry

z1171
All PDFs of this category
1171
Asymmetric Transfer Hydrogenation in Flow

Erratum

1172
Erratum: Scalable Synthesis of KRAS G12C Inhibitor GDC-6036