DOI: 10.1055/s-00000131

Synfacts

Issue 08 · Volume 15 · August 2019 DOI: 10.1055/s-009-43556

Synform

A113
Zanda, Matteo: SYNFORM ISSUE 2019/08

Synthesis of Natural Products and Potential Drugs

z0833
All PDFs of this category
0833
Synthesis of (+)-Longirabdiol, (–)-Longirabdolactone, and (–)-Effusin
0834
Synthesis of a PDE10A Inhibitor
0835
Synthesis of E2212
0836
Synthesis of Taselisib
0837
Synthesis of Taselisib
0838
Syntheses of (±)-Rhodomolleins XX and XXII
0839
Total Syntheses of (–)-Daphlongamine H and (–)-Isodaphlongamine H
0840
Total Synthesis of Englerins A and B
0841
Synthesis of (–)-7-Deacetoxyalcyonin Acetate
0842
Synthesis of a Renin Inhibitor
0843
Synthesis of a TAK-480 Fragment
0844
Synthesis of TAK-063
0845
Synthesis of (+)-Arborisidine
0846
Synthesis of Dolutegravir
0847
Synthesis of Dolutegravir
0848
Synthesis of an Edoxaban Fragment
0849
Synthesis of (+)-Principinol D
0850
Synthesis of Tofogliflozin
0851
Synthesis of BMS-986236

Synthesis of Heterocycles

z0853
All PDFs of this category
0853
Synthesis of Two Azaborine Building Blocks
0854
Phosphonium-Salt-Catalyzed Synthesis of Fused Aziridines by an Aza-Darzens Reaction
0855
Chemoselective Demethylation of Methoxypyridines over Anisoles
0856
Catalytic Azole Acylation with Acyl Fluorides
0857
Acridone Synthesis by Double Amination of Dibromobenzophenones
0858
Enantioselective Catalytic Aryl-Alkenylation To Give Dihydrobenzofurans
0859
Synthesis of 1,2-Benzothiazine 1-Imines as New Heterocyclic Scaffolds
0860
Selective C–H Alkenylation of Isoxazoles
0861
Gold(III)-Catalyzed Synthesis of 4-Aminooxazoles
0862
Synthesis of 1,4-Benzothiazines by Iodide-Catalyzed Alkene Sulfenoamination
0863
Copper-Catalyzed Synthesis of 3,4-Dihydroquinazolines from Anthranils
0864
Silver-Catalyzed Synthesis of Trifluoromethylated Triazines and Pyridines
0865
Asymmetric Synthesis of Dihydrobenzofurans by an Organocatalytic [4+1] Cyclization
0866
DBU-Mediated Synthesis of Bicyclic Heterocycles

Synthesis of Materials and Unnatural Products

z0867
All PDFs of this category
0867
A Prefix to SuFEx
0868
The Whole Kit and Caboodle: A Ferrocenyl Halogen Bonding Rotaxane for Electrochemical Bromide Sensing
0869
It takes Strained Alkynes to make Polycyclic Aromatic Hydrocarbons
0870
Forced into Antiaromaticity
0871
Tetrahydroquinoline-Fused Fullerenes
0872
(N-Phenylfluorenylidene)acridanes: Mechanochromic BAEs
0873
Organocopper Cross-Coupling for Crowded Environments
0874
Deep LUMO Level Diimide π-Electron Core
0875
Renewing the Synthesis of Sterically Hindered Phenanthrenes
0876
Studies of Polyarylether COFs
0877
Cranking out Functionalized Helicenes
0878
Unlocking a [2.2.2]Carbon Nanocage

Metals in Synthesis

z0879
All PDFs of this category
0879
Diastereoselective [4+4] Cycloadditions
0880
Asymmetric Copper-Catalyzed Hydroamination of Enamines
0881
Iridium-Catalyzed Asymmetric Hydroalkynylation of Unactivated Alkenes
0882
Nickel-Catalyzed Amination of Phenols
0883
Mild Copper-Catalyzed N-Arylation of Sulfoximines
0884
Enantioselective Synthesis of Chiral Homoallylic Tertiary Alcohols through Copper Catalysis
0885
Dual Nickel/Photo-Catalyzed Esterification of Aryl Halides
0886
Nickel-Catalyzed Cyano-Borrowing Reaction Affording β-Cyano Ketones
0887
Cobalt-Catalyzed Aminocarbonylation of Alkyl Tosylates
0888
Synthesis of Chiral β-Nitroamides
0889
Enantioselective Synthesis of Tertiary α-Silyl Alcohols
0890
The Catalytic Kulinkovich Reaction
0891
Synthesis of Areneamides
0892
Intermolecular [2+2] Carbonyl–Olefin Photocycloadditions Enabled by a Copper(I)–Norbornene Complex
0893
Regioselective Palladium-Catalyzed C–H Iodination of Alkenes
0894
Amide Enolate Surrogates in Asymmetric Allylation Reactions
0895
Catalytic Preparation of Potassium Acyltrifluoroborates
0896
Amination of Triaryl Phophates
0897
Palladium-Catalyzed Dearomative Carboamination
0898
Counterion-Controlled Cobalt-Catalyzed Addition of Cyclopropanols to Oxabyciclic Alkenes
0899
Palladium-Catalyzed Enantioselective N‑Alkylation of Indoles
0900
Decarboxylative Alkylation
0901
Iodination/Cross-Coupling Cascade Reaction
0902
Radical-Driven Deoxygenation of Secondary Alcohols: The Barton–McCombie Reaction
0903
Nickel-Catalyzed Reaction of Umpolung Carbonyls and Alkyl Halides
0904
Ligand-Controlled Selection of Diastereoisomers in Asymmetric 1,3-Dipolar Cycloaddition
0905
Ruthenium-Catalyzed Transfer Hydrogenation of α-Acetamido Benzocyclic Ketones
0906
Intramolecular Asymmetric Hydroamination of Allenes
0907
Preparation of 2-Substituted Propenes
0908
Nickel/Manganese Dual-Catalyzed Hydroalkylation of Olefins

Polymer-Supported Synthesis

z0909
All PDFs of this category
0909
Ion-Exchange-Resin-Supported Hydrogen Fluoride for Fluorination Reactions
0910
Michael Addition on a Squaramide-Decorated Covalent Organic Framework
0911
Aqueous Flow Hydroxycarbonylation on an Amphiphilic Polymer-Supported Pd Complex
0912
Transfer Hydrogenation of Aryl Ketones on Mesoporous Silica-Supported Nickel
0913
Buchwald–Hartwig Amination on NHC-Pd Immobilized on Wang Resin
0914
Couplings of Aryl Halides with Arylboronic Acids on Silica-Supported Nickel
0915
Palladium-Catalyzed Dehydrogenative Aromatization of Cyclic Amines
0916
Dehydrogenation of N-Heterocycles with Cobalt Nanocrystals on Carbon
0917
Suzuki–Miyaura Coupling on Aluminosilicate-Encapsulated Palladium Nanoparticles
0918
Benzylic C(sp3)–H Bond Oxidation Catalyzed by a Supported Manganese Complex
0919
Alumina-Supported Copper Oxide Hydrogenation Catalyst
0920
Hydroxylation of Alkyl Halides on an Aminopolystyrene-Supported Ionic Liquid
0921
Nickel-Catalyzed Cross-Coupling of Aryl Chlorides with Organolithiums
0922
Porous NiCo-Catalyzed Reduction of Nitroarenes with Ammonia Borane

Organo- and Biocatalysis

z0923
All PDFs of this category
0923
Enzyme-Catalyzed Site-Selective C–H Amidation
0924
Chiral Phosphine Catalyzed Asymmetric Staudinger–aza-Wittig Reaction
0925
Photochemical Organocatalytic Borylation of Alkyl Halides and Sulfonates
0926
Benzothiophene-Catalyzed Oxidative Coupling of 2-Naphthols
0927
Benziodoxole-Catalyzed Anti-Markovnikov Hydroazidation of Olefins
0928
Organocatalytic Enantioselective Dichlorination of Cyclic Styrenes
0929
[4+2] Cycloaddition via NHC-Bound Aza-ortho-Quinone Methides
0930
Diazaphospholene-Catalyzed Reductive Ireland–Claisen Rearrangement
0931
Asymmetric Catalytic Transannular Morita–Baylis–Hillman Reaction
0932
A Bifunctional Catalyst Permits Atroposelective Aromatization
0933
Enantioselective Protonation of Disilyl Ketene Acetals with Water or Methanol
0934
Thiazolium Salt Catalyzed Asymmetric Benzoin Reaction

Chemistry in Medicine and Biology

z0935
All PDFs of this category
0935
A Mitochondria-Targeting Calcium Dye
0936
Small-Molecule Inhibitors of CRISPR-Cas9
0937
In Vivo Imaging of Glucose Uptake
0938
Chemical Diversification of Pleuromutilin
0939
Highly Selective Insulin-Degrading Enzyme Inhibitors
0940
Selective α-Glycosidation of Sialic Acid
0941
Short Synthesis of the 3-Deazaguanosine RNA Building Block
0942
SCOTfluors: Small, Conjugatable, Orthogonal, and Tunable Fluorophores
0943
Photoactivated Fluxional Fluorophore Enables Extended Time-Lapse Microscopy

Peptide Chemistry

z0945
All PDFs of this category
0945
Organcatalytic Transamination for the Synthesis of α-Amino Acids
0946
One-Pot Four-Component Strategy for Electrophilic Fluorination
0947
Site-Selective Reduction of Cyclosporine A by Borane Catalysis
0948
Palladium-Catalyzed β-C–H Arylation of N-Methylated Peptides
0949
Synthesis of Rigidified Cyclic Peptides by Ring-Closing Metathesis
0950
Azotide Ligands for Hetero-Diels–Alder Reactions
0951
Synthesis of N-Terminal Cysteinyl Thioesters
0952
Nickel-Catalyzed Synthesis of Amides from Methyl Esters
0953
Pd-Catalyzed Arylation of α-Amino Esters with Diaryliodonium Triflates

Flow Chemistry

z0955
All PDFs of this category
0955
Continuous-Flow Preparation of Alkynylzinc and its Subsequent Cross-Coupling Reaction
0956
Continuous-Flow Electrochemical Oxidation with Hypervalent Iodine Reagents
0957
Syntheses of Sulfilimines and Sulfoximines in a Flow System
0958
Flow Synthesis of Vaborbactam
0959
Flow Synthesis of Ceramide d-erythro-CER[NDS]
0960
Synthesis of Sialic Acid Derivatives in a Continuous-Flow Enzymic Reactor
0961
Cascade Oxidation over Contiguous Dual Catalyst Beds in Continuous Flow

Erratum

0962
Ramkumar, N; Van Meervelt, L; Van der Eycken, E V: Iron-Catalyzed Synthesis of Fluoroalkylated 2H-Azirines from Alkynes
0962
Jasiak, A; Mielniczak, G; Owsianik, K; Koprowski, M; Krasowska, D; Drabowicz, J: Continuous-Flow, Michaelis−Arbuzov Rearrangement