Azotide Ligands for Hetero-Diels–Alder Reactions
Azotides as Modular Peptide-Based Ligands for Asymmetric Lewis Acid Catalysis.
J. Org. Chem. 2019;
18 July 2019 (online)
Azotides, which are abundantly found as scaffolds in natural products, are known to coordinate metal ions. The author report new azotide ligands for enantioselective Lewis acid catalysis.
The ligands were readily prepared from the chiral pool of amino acids and demonstrated enantioselectivity when used as ligands in a cobalt(II)-catalyzed hetero-Diels–Alder reaction.