DOI: 10.1055/s-00000131

Synfacts

Issue 07 · Volume 15 · July 2019 DOI: 10.1055/s-009-43306

Synform

A97
Zanda, Matteo: SYNFORM ISSUE 2019/07

Synthesis of Natural Products and Potential Drugs

z0699
All PDFs of this category
0699
Total Synthesis of (+)-Flavisiamine F
0700
Synthesis of an HCV NS5B RNA Polymerase Inhibitor
0701
Synthesis of AZD7594
0702
Synthesis of GSK8175
0703
Synthesis of BMS-986094
0704
Synthesis of Cephalotaxus Alkaloids
0705
Synthesis of a HCV NS5B Nucleoside Polymerase Inhibitor
0706
Synthesis of a BACE 1 Inhibitor
0707
Synthesis of (–)-Himalensine A
0708
Synthesis of Dasabuvir
0709
Synthesis of (+)-Biotin
0710
Synthesis of BMS-919373
0711
Synthesis of Tesirine
0712
Synthesis of (±)-Phalarine
0713
Synthesis of ABBV-168
0714
Synthesis of Speradine C
0715
Synthesis of AMG 232
0716
Synthesis of Veliparib
0717
Synthesis of GDC-0908
0718
Synthesis of Venetoclax
0719
Synthesis of BMS-911543
0720
Syntheses of (+)-Pseudopteroxazole and (+)-Ileabethoxazole

Synthesis of Heterocycles

z0721
All PDFs of this category
0721
Bithiophenes as a New Class of Organic Photoredox Catalysts
0722
Programable Synthesis of Polyspirocyclic Heterocycles
0723
Combined Electrochemical and Photochemical Syntheses of Pyrrolidines and Oxazolines
0724
Synthesis of 1,3,4-Thiadiazines from Fluorinated Nitrile Imines and Thiols
0725
Synthesis of Pyrazoles by a Silver-Mediated [3+2]-Cycloaddition Reaction
0726
Rhodium(III)-Catalyzed Synthesis of (2H)-Indazoles from Azobenzenes
0727
Synthesis of Fused Indoline–Cyclobutanone Derivatives
0728
Decarboxylative Fluorination of Pyridin-2-ylacetates
0729
Synthesis of 5,5-Disubstituted Hydantoins
0730
Copper-Catalyzed Synthesis of Substituted Indoles and Benzoindoles
0731
Base-Catalyzed Annulation for the Synthesis of Pterocarpene Analogues
0732
Azepines by Palladium-Catalyzed C–H Activation and Isocyanide Insertion
0733
Silver-Catalyzed Synthesis of 4-Trifluoromethyl-1,2,3-triazolines
0734
Manganese-Catalyzed Selective C–H Alkylation of Imidazopyridines
0735
Thiomorpholine Synthesis by a Copper-Catalyzed Three-Component Reaction

Synthesis of Materials and Unnatural Products

z0737
All PDFs of this category
0737
Devising Rules of Thumb for a Bis(tetrathiofulvalene) Molecular Switch
0738
Accio peri-Acenoacenes
0739
Ladder to Conjugation
0740
Can’t Buy These Earrings at Tiffany’s
0741
Pyrazolyl Heptazine, You Make It Easy!
0742
Sustainable Polymers Just Got a Little Bit Sweeter
0743
A Short Route to BN-Heteroarenes
0744
BN-Embedded PAHs Functionalized in Crossed Directions
0745
Stitching to Make Substituted Fluorenes
0746
DCPP-Based Bowl-Shaped Hydrocarbons
0747
A Linear Nonacene Analogue
0748
Towards 3D Semiconducting Nanostructures

Metals in Synthesis

z0749
All PDFs of this category
0749
Palladium-Catalyzed Generation of C1 Ammonium Enolates
0750
Iron-Catalyzed Thiolation of Azetidines
0751
Di- and Tri-substituted Alkenyl Nitriles
0752
Copper-Catalyzed Enantioselective Cyanofluoroalkylation of Alkenes Induced by Visible Light
0753
Enantioselective Copper-Catalyzed Diels–Alder Cycloaddition
0754
Photoredox-Catalyzed Trifluoromethylation
0755
Photoredox-Catalyzed Hydroamidation of Olefins
0756
Asymmetric Light-Mediated Radical Cyanation
0757
Tele-Nucleophilic Substitution
0758
P-Stereogenic Centers via Thulium(III)-Catalyzed Desymmetrization of Dialkynylphosphine Oxides
0759
Preparation of Branched/Linear Ketones via a Regiodivergent Rhodium-Catalyzed Reductive Coupling
0760
Regio- and Enantioselective Indole Allylation
0761
Synthesis of Ketones, Alcohols, and Amines by Anionic Chemistry
0762
Mechanism-Based Optimization of the Palladium-Catalyzed Amination of Aryl Triflates
0763
Enantioselective Allylic Alkylation of β,α-Unsaturated α-Amino Nitriles
0764
Copper-Catalyzed Allylation of Imines via Umpolung
0765
Functionalization of C–H Bonds of Aliphatic Alcohols
0766
Light-Mediated Ruthenium-Catalyzed Olefin Metathesis
0767
Rhodium(III)-Catalyzed Cyclopropanation of Allylic Alcohols
0768
Enantioselective Rhodium-Catalyzed Synthesis of C–N Axially Chiral N-Aryloxindoles
0769
Dual-Catalyzed Dihydrofunctionalization of Terminal Alyknes
0770
Iridium-Catalyzed Enantioselective C(sp3)–H Amidation
0771
Axially Chiral Biaryl Compounds via Cu-Catalyzed Acyloxylations of Cyclic Diaryliodonium Salts
0772
ortho-Thiolation via the Catellani Reaction
0773
Asymmetric Synthesis of Alkyl Fluorides
0774
Rhodium-Catalyzed Transfer Hydroformylation of Alkynes
0775
The Birch Reduction
0776
Palladium-Catalyzed syn-Hydrocarboxylation of Alkynes Utilizing Hydroxy Groups
0777
Enantioselective Rhodium-Catalyzed Benzylic C(sp3)–H Amination

Polymer-Supported Synthesis

z0779
All PDFs of this category
0779
Co-Synthesis of Glycolic Acids, Formamides, and Formates on Copper/Alumina
0780
α-Alkylation of β-Diketones with Alkenes or Alcohols on Graphene Oxide
0781
Synthesis of 1,2,4-Triazoles on Mesoporous Silica-Supported Copper(I) Bromide
0782
Cadmium Sulfide Photocatalyzed Nickel-Mediated C–O and C–N Coupling of Aryl Bromides
0783
Cobalt-Catalyzed C–H Sulfonylation of Tetrahydroquinoxalines
0784
Cobalt-Catalyzed Reductive Coupling of Nitroarenes with Alcohols
0785
Dehydrogenative Silylation of Terminal Alkynes on AuPd Nanoalloys
0786
Self-Assembled Polymeric Pyridine–Copper Catalyst for Huisgen Cycloaddition
0787
Synthesis of Triarylpyridines on an Iron–Organic Framework
0788
Hydroarylation of Alkynes and Alkenes Catalyzed by Alumina-Sulfuric Acid
0789
γ-Lactam Synthesis by Reductive Amination of Ethyl Levulinate on AuPd Nanoparticles
0790
Pd/C-Catalyzed Reductive N-Methylation of Quinolines

Organo- and Biocatalysis

z0791
All PDFs of this category
0791
Phosphine/Iodide-Based Photoredox-Catalyzed Decarboxylative Alkylations
0792
Chiral Brønsted Acid-Catalyzed Direct Reductive Amination with Silanes
0793
Phthalidyl Ester Prodrugs by Catalytic Asymmetric Acetalization of Carboxylic Acids
0794
Synthesis of Tricyclic Scaffolds through Photochemical and Prins–Ritter Reactions
0795
Machine Learning-Assisted Directed Evolution of Proteins
0796
An Enzyme-Catalyzed Inverse-Electron-Demand Diels–Alder Reaction
0797
Regioselective Vinylogous Aldol Condensation of α,β-Unsaturated Aldehydes
0798
Toward Chiral 1,4-Enynes: Asymmetric Alkenylation of Propargyl Alcohols
0799
Catalytic Asymmetric Alkylations via Phase-Transfer Catalysis
0800
Organocatalytic Baeyer–Villiger Oxidation for the Synthesis of Prostaglandins
0801
Cyclization of 2-Methylene-2H-indols with ortho-Quinone Methides Generated In Situ

Chemistry in Medicine and Biology

z0803
All PDFs of this category
0803
An in Vivo Mass Cytometry Probe for Protein Translation
0804
Sulfonium Sugars with Antidiabetic Activities
0805
Synthesis of the Smallest Cyclodextrins
0806
Sphingosine-1-phosphate Photopharmacology
0807
Optical Control of Cardiac Function
0808
C–H Activation and Decarboxylative Cross-Coupling of Carboxylic Acids
0809
Targeting Myc through Stabilization of the Max Homodimer
0810
Activity-Based Profiling of Bile Salt Hydrolases
0811
The First Method to Sequence DNA
0812
A Route to Complex N-Arylated Alkylamines via Photocatalytic C–H Amination
0813
Optimizing Triarylborane Fluorophores for Biological Applications
0814
Bioinspired Histidine Bioconjugation

Peptide Chemistry

z0815
All PDFs of this category
0815
Synthesis of Disubstituted Peptidoisoxazoles
0816
Organcatalysis for the Synthesis of α,α-Difluoro-β-Amino Amides
0817
Photoredox-Catalyzed Decarboxylative Alkynylation of Peptides
0818
Cooperative Catalysis for Enantioselective α-Allylic Alkylation
0819
Peptide C(sp2)–O Cross-Coupling by Nickel/Photoredox Dual Catalysis
0820
Photocatalyzed Efficient Synthesis of C-Glycoamino Acids
0821
Efficient Peptide Coupling for the Total Synthesis of Echinocandins
0822
Zn/Cu(OTf)2-Mediated 1,4-Addition of Alkyl/Aryl Halides to Dehydroalanine
0823
β-Aryl-β-pyrazolyl α-Amino Acid Synthesis by Copper Catalysis
0824
Copper-Catalyzed 1,4-Reduction of N-Aryl β-Enamino Esters
0825
Total Synthesis of the Cyclic Tetrapeptide Pseudoxylallemycin A
0826
Construction of Peptide Linkages by Using Sulfuryl Fluoride

Flow Chemistry

z0827
All PDFs of this category
0827
A Rapid Flow Synthesis of Linezolid
0828
Scandium-Catalyzed Electrochemical Intramolecular Cross-Coupling
0829
Continuous-Flow Diastereoselective Synthesis of Substituted Tetrahydrofurans
0830
Ynones and Pyrazoles in Continuous Flow
0831
Thermolytic Deprotection of N-Boc Groups
0832
Continuous-Flow Production of 5-(Hydroxymethyl)furfural