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Synfacts 2019; 15(07): 0751
DOI: 10.1055/s-0039-1689949
Metals in Synthesis
© Georg Thieme Verlag Stuttgart · New York

Di- and Tri-substituted Alkenyl Nitriles

Contributor(s):
Paul Knochel
,
Moritz Balkenhohl
Mu Y, Nguyen TT, Koh MJ, Schrock RR, Hoveyda AH. * Boston College, Chestnut Hill and Massachusetts Institute of Technology, Cambridge, USA
E- and Z-, Di- and Tri-substituted Alkenyl Nitriles through Catalytic Cross-Metathesis.

Nat. Chem. 2019;
11: 478-487
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Further Information

Publication History

Publication Date:
17 June 2019 (online)

 
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Key words

alkenyl nitriles - cross-metathesis - molybdenum catalysis

Significance

Hoveyda and co-workers disclose the preparation of E- and Z-multiply-substituted alkenyl nitriles in high yields and excellent dia­stereoselectivities through molybdenum-catalyzed cross-metathesis reactions.


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Comment

The choice of the molybdenum catalysis discussed in detail and the application of the methodology is demonstrated by the preparation of a wide range of biologically active substrates.


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