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Synfacts 2019; 15(07): 0749
DOI: 10.1055/s-0039-1689958
DOI: 10.1055/s-0039-1689958
Metals in Synthesis
Palladium-Catalyzed Generation of C1 Ammonium Enolates
Li L.-L,
Ding D,
Song J,
Han Z.-Y.
*
Gong L.-Z.
* University of Science and Technology of China, Hefei and Collaborative Innovation Center of Chemical Science and Engineering, Tianjin, P. R. of China
Catalytic Generation of C1 Ammonium Enolates from Halides and CO for Asymmetric Cascade Reactions.
Angew. Chem. Int. Ed. 2019;
58: 7647-7651
Catalytic Generation of C1 Ammonium Enolates from Halides and CO for Asymmetric Cascade Reactions.
Angew. Chem. Int. Ed. 2019;
58: 7647-7651
Further Information
Publication History
Publication Date:
17 June 2019 (online)
Significance
The authors disclose a palladium-catalyzed generation of C1 ammonium enolates from readily available halides, carbon monoxide, and catalytic chiral Lewis base. The intermediate participated in asymmetric reactions with ketimines.
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Comment
The chiral dihydropyridone and β-lactam products were obtained in high yields, high diastereoselectivities, and excellent enantioselectivities. This methodology was employed in the asymmetric synthesis of an antiproliferative agent.
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