DOI : 10.1055/s-00000054

Pharmacopsychiatry

Ausgabe 06 · Volume 25 · Dezember 2015 DOI: 10.1055/s-005-30053


Abstracts of the 29th Symposium of the AGNP
Munich, 23rd–26th September 2015

Chairs: Stefan Bleich, Hannover; Jens Wiltfang, Göttingen; Dirk Wedekind, Göttingen
Abstracts (HTML) Autorenliste
A0
Bleich, S; Wiltfang, J; Wedekind, D: Editorial/Opening Words
A1
Adamovic, I; Sagebiel, A; Grohmann, R; Toto, S; Degner, D: Adverse drug reactions: vascular parkinsonism and sedation – a pharmacokinetic and pharmacodynamic evaluation from the German Pharmacovigilance project AMSP
A2
Adamovic, I; Timäus, C; Klipper, T; Havemann-Reinecke, U: Stimulation of GABA-A (Diazepam) and GABA-B (Baclofen) receptor by a benzodiazepine depended patient: intoxication, clinic, treatment – a case report
A3
Ambree, O; Ruland, C; Zwanzger, P; Arolt, V; Alferink, J: Altered myeloid and lymphoid immune cell responses following repeated social defeat stress
A4
Böhr, S; Haen, E: Therapeutic drug monitoring of direct oral anticoagulants (DOAC)/UHPLC method for simultaneous determination of direct oral anticoagulants in human plasma
A5
Bartz, J; Berger, C; Thome, J; Höppner, J: Psychomotor dysfunction in depression
A6
Breitenstein, B; Scheuer, S; Brückl, T M; Meyer, J; Ising, M; Uhr, M; Holsboer, F: Optimizing antidepressant treatment dosage based on ABCB1 gene variants – Results from a randomized clinical study
A7
Calzavara, E; Haen, E: Drug interactions in geriatic patients treated with venlafaxine
A8
Curic, S; Thiebes, S; Polomac, N; Steinmann, S; Eichler, I; Eichler, L; Zöllner, C; Leicht, G; Mulert, C: Reduced early auditory evoked gamma-band response in ketamine model of schizophrenia
A9
Elbau, I; Brücklmeier, B; Spoormaker, V; Binder, E; Czisch, M; Sämann, P G: Acute psychosocial stress investigated by an imaging stress test: concept and preliminary results
A10
Elbau, I; Ising, M; Uhr, M; Schaaf, L; Holsboer, F; Lucae, S; Kloiber, S: Thyroid disorders are associated with impaired response to psychopharmacological treatment of major depression
A11
Engler, L; Kuenzel, H; Riester, A; Dietz, A; Yassouridis, A; Reincke, M; Steiger, A: Differences in polysomnography between patients suffering from Connʼs syndrome in comparison with a control group
A12
Esselmann, H; Hafermann, C; Jahn, O; Kraus, I; Vogelgsang, J; Haußmann, U; Uecker, M; Liepold, T; Klafki, H; Wiltfang, J: Analytical methods to explore Amyloid-β-Peptide variants beyond Aβ1-40 and Aβ1-42
A13
Falter, T; Schmitt, V; Boeschen, S; Herold, S; Hefner, G; Weyer, V; Auer, C von; Lämmle, B; Rossmann, H; Scharrer, I; Lackner, K: Prevalence of Depression in patients with diagnosis of thrombotic thrombocytopenic purpura (TTP)
A14
Fay, B; Seifert, J; Strueven, N T; Wenzel-Seifert, K; Haen, E: The sedative burden
A15
Filiou, M D; Arefin, A S; Moscato, P; Graeber, M B: Alzheimerʼs disease, Parkinsonʼs disease and schizophrenia are not inflammatory diseases while inflammation is recognizable beyond organ borders
A16
Filiou, M D; Webhofer, C; Guillermier, C; Poczatek, C; Wang, M; Turck, C W; Lechene, C P: Hippocampal protein turnover alterations in response to antidepressant treatment
A17
Filiou, M D; Wood, P; Teplytska, L; Otte, D; Zimmer, A; Turck, C W: Altered myelination in schizophrenia: Evidence from animal models and human cohorts
A18
Helm, S; Kleimann, A; Birkenstock, A; Schuppner, R; Bleich, S; Krüger, T; Kahl, K; Frieling, H: The use of ketamine in treatment-resistant major depression: a case study
A19
Hennings, J M; Uhr, M; Klengel, T; Weber, P; Pütz, B; Touma, C; Czamara, D; Ising, M; Holsboer, F; Lucae, S: RNA expression profiling in depressed patients suggests retinoid-related orphan receptor alpha as a biomarker for antidepressant response
A20
Hiebel, C; Kromm, T; Stark, M; Behl, C: Cannabinoid receptor 1 modulates the autophagic flux in a non-canonic fashion
A21
Hohner, M; Hommers, L; Zebner, J; Deckert, J; Unterecker, S: QTc prolongation of amitriptyline and doxepin in relation to serum concentration and method of frequency correction
A22
Hüttenrauch, M; Brauß, A; Kurdakova, A; Klafki, H; Wiltfang, J; Wirths, O: Physical activity ameliorates neuron loss and memory deficits in Tg4-42 mice
A23
Ising, M; Zimmermann, P; Brückl, T; Pfister, H; Holsboer, F; Belcredi, P: Depression and burnout – Impact on sick leave and job satisfaction. Results from an epidemiological survey
A24
Jahn, H; Denk, J: MicroRNA profiling of CSF in Alzheimerʼs disease
A25
Jordan, K; Fromberger, P; Laubinger, H; Dechent, P; Müller, J L: Does the neural processing of visual sexual stimuli change under GnRH-therapy? A single case study in pedophilia
A26
Karch, S; Keeser, D; Paolini, M; Hümmer, S; Konrad, J; Haller, D; Kirsch, V; Koller, G; Kupka, M; Blautzik, J; Pogarell, O: Real-time fMRI neurofeedback: application in patients with substance use disorder
A27
Kraus, I; Kraus, I; Kraus, I; Besong-Agbo, D; Otto, M; Klafki, H; Klafki, H; Wiltfang, J; Wiltfang, J: Measurement of ERK1/2 Isoform distribution in peripheral blood mononuclear cells derived from whole blood from patients with different neuropsychiatric disorders
A28
Kunath, N; Kumar, A; Dozier-Sharpe, M; Allison, D B; Van Groen, T; Kadish, I: Ghrelin agonist does not foster insulin resistance but improves cognition in an Alzheimerʼs disease mouse model
A29
Kunath, N; Müller, N; Tonon, M; Kopczak, A; Steiger, A; Dresler, M: Ghrelin does not act as a short-term cognitive enhancer in young male humans
A30
Kunath, N; Müller, N; Tonon, M; Kopczak, A; Steiger, A; Dresler, M: Ghrelin does not act as a short-term cognitive enhancer in young male humans
A31
Kundermann, B; Cabanel, N; Haag, A; Müller, M J: Chronotype and its relationship to sleep quality in patients with affective disorders and co-occurring insomnia
A32
Kuzin, M; Lammertz, S E; Stegmann, B; Haen, E; Gründer, G; Paulzen, M: Effects of Proton Pump Inhibitors (PPI) on the serum concentrations of Venlafaxine
A33
Lammertz, S E; Gründer, G; Tauber, S; Veselinovic, T; Hiemke, C; Paulzen, M: Concentrations of Venlafaxine, Mirtazapine and Citalopram in serum and cerebrospinal fluid – a naturalistic approach
A34
Müller, M J; Cabanel, N; Haag, A; Olschinski, C; Kundermann, B: Chronotype distribution and stability in hospitalized patients with depression
A35
Müller, M J; Netter, P; Haag, A; Kundermann, B: Salivary testosterone and cortisol response following mild controllable or uncontrollable laboratory stress in healthy males
A36
Müller, M J; Rashid, D; Kundermann, B; Haag, A; Cabanel, N: Corrected qt time among patients treated with clozapine or quetiapine under clinical routine conditions
A37
Mechler, K; Häge, A; Niemeyer, L; Schumm, L; Ben Dau, M; Dittmann, R W: Subjective experience and medication adherence in adolescents with psychiatric disorders – preliminary findings from the Mannheim SEMA study
A38
Hüttenrauch, M; Brauß, A; Kurdakova, A; Klafki, H; Wiltfang, J; Wirths, O: Physical activity ameliorates neuron loss and memory deficits in Tg4-42 mice
A39
Mikoteit, T; Beck, J; Hemmeter, U; Brand, S; Bischof, R; Delini-Stula, A; Holsboer-Trachsler, E; Eckert, A: Assessment of serum levels of mature brain-derived neurotrophic factor (mBDNF) is not superior to total (tot)BDNF in prediction of antidepressant treatment outcome
A40
Mikoteit, T; Brand, S; Bürki, N; Hösli, I; Holsboer-Trachsler, E: Breastfeeding is associated with increased Non REM S3-sleep in non-depressive mothers three months post partum
A41
Chechko, N; Kellermann, T; Habel, U: Brain circuitries involved in emotional interference task in major depression and borderline personality disorders
A42
Ben Omar, N; Haen, E: Quantification of Eighteen Psychotherapeutic Agents and their metabolites Using Column Switching HPLC/UV
A43
Nussbaumer, M; Asara, J M; Teplytska, L; Murphy, M P; Landgraf, R; Turck, C W; Filiou, M D: Mitochondria as pharmacological targets for anxiolytic treatment
A44
Paulus, W E: Pregnancy outcome after use of zopiclone during first trimester
A45
Paulzen, M; Gründer, G; Veselinovic, T; Wolf, B; Hiemke, C; Lammertz, S: Duloxetine enters the brain – but why is it not found in the cerebrospinal fluid
A46
Paulzen, M; Lammertz, S E; Veselinovic, T; Goecke, T; Hiemke, C; Gründer, G: Psychopharmacotherapy during pregnancy: Therapeutic drug monitoring (TDM) in maternal blood, amniotic fluid and umbilical cord blood
A47
Koo, P C; Berger, C; Bartz, J; Wybitul, P; Thome, J; Hoeppner, J: Relationship between dynamic neural activities and clinical symptoms in depression
A48
Rampp, C; Eichelkraut, A; Best, J; Uhr, M; Binder, E B; Menke, A: Gender related differential response to dexamethasone in endocrine and immune measures in depressed patients and healthy controls
A49
Richter, A; Petrovic, A; Diekhof, E K; Trost, S; Wolter, S; Gruber, O: Hyperresponsivity and impaired prefrontal control of the mesolimbic reward system in schizophrenia
A50
Rothammer, C; Haen, E: Development of a method to determine caffeine in human serum by HPLC
A51
Sadeghi Bahmani, D; Farnia, V; Hojatitabar, S; Shakeri, J; Rezaei, M; Yazdchi, K; Bajoghli, H; Holsboer-Trachsler, E; Brand, S: Adjuvant Rosa damascena has a small effect on SSRI-induced sexual dysfunction in female patients suffering from MDD
A52
Sadeghi Bahmani, D; Farnia, V; Shakeri, J; Yazdchi, K; Bajoghli, H; Holsboer-Trachsler, E; Brand, S: The comparison of the effect of yoga and aquatic exercises on depression and fatigue in patients with multiple sclerosis
A53
Sämann, P; Elbau, I; Höhn, D; Schmaal, L; Czisch, M: Hippocampal subfield analysis to compare the depression and neurodegeneration spectrum
A54
Sämann, P; Gruber, O; Czisch, M: Impact of vigilance fluctuations on resting state fMRI functional connectivity analysis
A55
Sämann, P; Zannas, A; Carrillo, T; Binder, E: Structural MR correlates of epigenetic age acceleration
A56
Schuster, R; Koopmann, A; Kiefer, F: Calcium for the treatment of alcohol-dependence
A57
Stepan, J; Micale, V; Wotjak, C T; Eder, M: Enhanced endocannabinoid signaling boosts signal propagation through the hippocampal trisynaptic circuit and facilitates safety learning
A58
Stratmann, M; Sommer, J; Belke, M; Knake, S; Kircher, T; Konrad, C: Manual and automated segmentation of the human hippocampus in cerebral magnetic resonance images
A59
Stropahl, U; Köhler, H; Möckel, G; Braunroth, J; Wandschneider, R; Thome, J: Pregnancy and antipsychotics
A60
Thiebes, S; Curic, S; Polomac, N; Feroz, F; Steinmann, S; Eichler, L; Eichler, I; Zöllner, C; Leicht, G; Mulert, C: The effects of glutamatergic modulation on human auditory perception and behavioural changes in a Mismatch Negativity (MMN) paradigm
A61
Unholzer, S; Wolf, M; Köppl, A; Haen, E: Bipolar disorder: Development of an UHPLC-UV method for the determination of 8 psychiatric drugs in human serum
A62
Veselinovic, T; Vernaleken, I B; Janouschek, H; Paulzen, M; Gründer, G: Realationship between dopamine D2 receptor availability and cognitive performance and psychopathology in drug-free patients with schizophrenia
A63
Vogelgsang, J; Wiltfang, J; Masliah, E; Winkler, J; Klucken, J: Dopaminergic stimulation in a transgenic model of neurodegeneration restores decreased proliferation and viability in subventricular zone derived adult neural precursor cells
A64
Warrings, B; Deckert, J; Unterecker, S: Association between body weight and serum concentration of antidepressant drugs
A65
Wolf, L; Bauer, A; Melchner, D; Hallof-Buestrich, H; Stoertebecker, P; Haen, E; Kreutz, M; Sarubin, N; Milenkovic, V M; Wetzel, C H; Rupprecht, R; Nothdurfter, C: Enhancing neurosteroid synthesis – Relationship to the pharmacology of translocator protein (18 kDa) (TSPO) ligands and benzodiazepines
A66
Wrosch, J; Beckmann, D; Kornhuber, J; Groemer, T W: The effects of antipsychotic drugs on primary hippocampal networks developing under different electrical stimulation patterns
A67
Zeise, M; Morales, B; Rozas, C; Burgos, H; Hernández, A: Psychostimulants and metaplasticity
A68
Chrobok, A; Länger, A; Karch, S; Keeser, D; Lehmann, K; Leicht, G; Mulert, C; Eser-Valeri, D; Ertl-Wagner, B; Dieterich, M; Rupprecht, R; Pogarell, O: Anticipatory anxiety in phobic postural vertigo patients – functional indicators for anxiety-related disorder
A69
Cohrs, S; Goerke, M; Rodenbeck, A; Riemann, D; Wiedemann, K; Thome, J; Winterer, G; Kiefer, F: Decreased plasma orexin levels in subjects with impaired sleep quality
A70
Cohrs, S; Pülschen, D; Goerke, M; Thome, J; Schlack, R: Vitamin D and its relation to sleep disturbance and depressive symptomatology – Results of the German Health Interview and examination survey for adults
A71
Curic, S; Thiebes, S; Polomac, N; Steinmann, S; Eichler, I; Eichler, L; Zöllner, C; Leicht, G; Mulert, C: Reduced early auditory evoked gamma-band response in ketamine model of schizophrenia
A72
Elbau, I; Ising, M; Uhr, M; Schaaf, L; Holsboer, F; Lucae, S; Kloiber, S: Thyroid disorders are associated with impaired response to psychopharmacological treatment of major depression
A73
Falter, T; Schmitt, V; Boeschen, S; Herold, S; Hefner, G; Weyer, V; Auer, C von; Lämmle, B; Rossmann, H; Scharrer, I; Lackner, K: Prevalence of depression in patients with diagnosis of thrombotic thrombocytopenic purpura (TTP)
A74
Hennings, J M; Uhr, M; Klengel, T; Weber, P; Pütz, B; Touma, C; Czamara, D; Ising, M; Holsboer, F; Lucae, S: RNA expression profiling in depressed patients suggests retinoid-related orphan receptor alpha as a biomarker for antidepressant response
A75
Hensch, T; Sander, C; Wozniak, D; Glass, J; Mauche, N; Spada, J; Jawinski, P; Hegerl, U: Biological correlates of hypomanic personality: genetics, sleep and brain arousal
A76
Jahn, H; Denk, J: MicroRNA profiling of CSF in Alzheimerʼs disease
A77
Karch, S; Keeser, D; Paolini, M; Hümmer, S; Konrad, J; Haller, D; Kirsch, V; Koller, G; Kupka, M; Blautzik, J; Pogarell, O: Real-time fMRI neurofeedback: application in patients with substance use disorder
A78
Mauche, N; Sander, C; Jawinski, P; Enzenbach, C; Schönknecht, P; Hegerl, U; Hensch, T: Impact of chronic smoking on P3 components in a three-stimulus oddball paradigm
A79
Meyer-Roetz, S H; Scherbaum, N; Wiltfang, J; Benninghoff, J: Effects of the psychopharmacological treatment by an outpatient clinic by patients living in nursing homes
A80
Mueller-Siecheneder, F: Diagnosing and managing anticholnergic side effects in psychopharmcological treatments
A81
Chechko, N; Kellermann, T; Habel, U: Brain circuitries involved in emotional interference task in major depression and borderline personality disorders
A82
Neitzert, K; Albayram, Ö; Ambrée, O; Lundt, R; Karaca, I; Cron, M; Müller, C; Förster, I; Bilkei, A; Gorzo, A; Jessen, F; Walter, J; Scheu, S; Maier, W; Zimmer, A; Alferink, J: CCL17-deficiency alters myeloid cell-responses and prevents cognitive decline in APP/PS1-mice
A83
Nussbaumer, M; Asara, J M; Teplytska, L; Murphy, M P; Landgraf, R; Turck, C W; Filiou, M D: Mitochondria as pharmacological targets for anxiolytic treatment
A84
Paulus, W E: Pregnancy outcome after use of zopiclone during first trimester
A85
Paulzen, M; Lammertz, S E; Veselinovic, T; Goecke, T; Hiemke, C; Gründer, G: Psychopharmacotherapy during pregnancy: Therapeutic drug monitoring (tdm) in maternal blood, amniotic fluid and umbilical cord blood
A86
Pogarell, O; Karch, S; Dunkel, G; Segmiller, F; Engelbregt, H; Keeser, D: Resting state EEG and functional connectivity in patients with major depression and under electro-convulsive therapy
A87
Rossner, M; Hasan, A; Falkai, P; Klebl, B; Wehr, M: Building academic-industrial alliances to stimulate drug discovery for psychiatric diseases
A88
Ruland, T; Domschke, K; Schütte, V; Zavorotnyy, M; Kugel, H; Notzon, S; Vennewald, N; Ohrmann, P; Arolt, V; Pfleiderer, B; Zwanzger, P: Neuropeptide S receptor gene variation modulates glutamatergic anterior cingulate cortex activity during CCK-4 induced panic
A89
Sadeghi Bahmani, D; Farnia, V; Hojatitabar, S; Shakeri, J; Rezaei, M; Yazdchi, K; Bajoghli, H; Holsboer-Trachsler, E; Brand, S: Adjuvant Rosa damascena has a small effect on SSRI-induced sexual dysfunction in female patients suffering from MDD
A90
Sadeghi Bahmani, D; Farnia, V; Shakeri, J; Yazdchi, K; Bajoghli, H; Holsboer-Trachsler, E; Brand, S: The comparison of the effect of yoga and aquatic exercises on depression and fatigue in patients with multiple sclerosis
A91
Sadeghi Bahmani, D; Jahangard, L; Akbarian, S; Haghighi, M; Ahmadpanah, M; Keshavarzi, A; Bajoghli, H; Holsboer-Trachsler, E; Brand, S: Children suffering from ADHD improved in behavior when treated with methylphenidate and adjuvant risperidone, compared to methylphenidate only, though weight gain was also observed – results from a randomized, double-blind, placebo-controlled clinical trial
A92
Sadeghi Bahmani, D; Shayganfard, M; Haghighi, M; Ahmadpanah, M; Pirdehghan, A; Bajoghli, H; Holsboer-Trachsler, E; Brand, S: Repetitive Transcranial Magnetic Stimulation (rTMS) improves symptoms and reduces clinical illness in patients suffering from OCD – Results from a single-blind, randomized clinical trial with sham cross-over condition
A93
Sämann, P; Elbau, I; Höhn, D; Schmaal, L; Czisch, M: Hippocampal subfield analysis to compare the depression and neurodegeneration spectrum
A94
Sämann, P; Gruber, O; Czisch, M: Impact of vigilance fluctuations on resting state fMRI functional connectivity analysis
A95
Sämann, P; Zannas, A; Carrillo, T; Binder, E: Structural MR correlates of epigenetic age acceleration
A96
Schmidt, F M; Sander, C; Dietz, M E; Nowak, C; Schröder, T; Himmerich, H; Schönknecht, P; Hegerl, U: EEG-measured vigilance regulation as response predictor for antidepressant therapy in major depression (VIRAP)
A97
Stepan, J; Micale, V; Wotjak, C T; Eder, M: Enhanced endocannabinoid signaling boosts signal propagation through the hippocampal trisynaptic circuit and facilitates safety learning
A98
Strauss, M; Paucke, M; Sander, C; Hegerl, U: Vigilance regulation in adult ADHD
A99
Zeise, M; Burgos, H; Cofré, C; Hernández, A; Saez, P; Morales, B: Methylphenidate induces long-lasting changes in synaptic plasticity after repetitive administration in adolescent rats
A100
Zeise, M; Morales, B; Rozas, C; Burgos, H; Hernández, A: Psychostimulants and metaplasticity
A101
Vogelgsang, J; Wiltfang, J; Masliah, E; Winkler, J; Klucken, J: Dopaminergic stimulation in a transgenic model of neurodegeneration restores decreased proliferation and viability in subventricular zone derived adult neural precursor cells
A102
Zilles, D; Folsche, T: Case report: Effectiveness of inhalative loxapin in the treatment of therapy refractory agitation
A103
Mavridou, K; Wiltfang, J: Clozapine for the treatment-resistant symptoms of derealisation and obsessive ruminations – A clinical case report
A104
Antonios, G; Borgers, H; Pilot, T; Pena, V; Bayer, T A: NT4X-167; Novel N-terminal Aβ specific antibody, prevents in vitro and in vivo toxicity of highly toxic Aβ4-42 species
A105
Richter, A; Petrovic, A; Diekhof, E; Trost, S; Wolter, S; Gruber, O: Hyperresponsivity and impaired prefrontal control of the mesolimbic reward system in schizophrenia
A106
Goya-Maldonado, R; Brodmann, K; Keil, M; Trost, S; Dechent, P; Gruber, O: Network fingerprints to distinguish bipolar and unipolar depression by fMRI
A107
Wedekind, D: Plasma tryptophan and clinical phenotypes in alcohol addicted males during acute tryptophan depletion depend on 5HTTPR-polymorphism
A108
Wedekind, D; Havemann-Reinecke, U: Disulfiram and relapse-prevention in alcohol addiction
A109
Warrings, B; Deckert, J; Unterecker, S: Association between body weight and serum concentration of antidepressant drugs
A110
Riedel, C; Broich, K; Escherich, A; Sudhop, T; Fritze, J: Evaluation of the extend of off-label use among the most common prescribed medicinal products based on data of the Statutory health insurance system in Germany – Design of the Evaluation
A111
Kraus, I; Besong Agbo, D; Otto, M; Klafki, H; Wiltfang, J: Measurement of ERK1/2 isoform distribution in peripheral blood mononuclear cells derived from whole blood from patients with different neuropsychiatric disorders