A Synthesis of Cyanolide A by Intramolecular Oxa-Michael Addition

Abstract

A synthesis of cyanolide A, a diolide natural product, has been achieved using a diastereoselective Barbier reaction, early-stage glycosylation, and intramolecular oxa-Michael addition to form the THP ring.

Key words

Michael addition - Barbier reaction - cyclisation - glycosylation - natural products

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