Synthesis 2014; 46(13): 1731-1738
DOI: 10.1055/s-0033-1341153
paper
© Georg Thieme Verlag Stuttgart · New York

A Synthesis of Cyanolide A by Intramolecular Oxa-Michael Addition

Roderick W. Bates*
Division of Chemistry and Biological Chemistry, School of Physical and Mathematical Sciences, Nanyang Technological University, Singapore 637371, Fax: +65(6791)1961   eMail: roderick@ntu.edu.sg
,
Tee Guan Lek
Division of Chemistry and Biological Chemistry, School of Physical and Mathematical Sciences, Nanyang Technological University, Singapore 637371, Fax: +65(6791)1961   eMail: roderick@ntu.edu.sg
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Publikationsverlauf

Received: 08. Februar 2014

Accepted after revision: 14. März 2014

Publikationsdatum:
22. April 2014 (online)


Abstract

A synthesis of cyanolide A, a diolide natural product, has been achieved using a diastereoselective Barbier reaction, early-stage glycosylation, and intramolecular oxa-Michael addition to form the THP ring.

Supporting Information