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Synfacts 2011(12): 1314-1314  
DOI: 10.1055/s-0031-1289322
Metal-Catalyzed Asymmetric Synthesis and Stereoselective Reactions
© Georg Thieme Verlag Stuttgart ˙ New York

Copper-Catalyzed Asymmetric α-Arylation of N-Acyloxazolidinones

Contributor(s): Hisashi Yamamoto, Kimberly Griffin
A. Bigot, A. E. Williamson, M. J. Gaunt*
University of Cambridge, UK
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Publication History

Publication Date:
18 November 2011 (online)

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Significance

The α-aryl carbonyl motif is commonly seen in pharmaceutical molecules and chiral building blocks, necessitating the use of asymmetric catalysts for their syntheses. The authors use a copper(II)-bisoxazoline catalyst system in conjunction with iodonium salts to achieve high yields and enantioselectivities for this transformation.