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Synfacts 2011(10): 1092-1092  
DOI: 10.1055/s-0030-1261131
Metal-Catalyzed Asymmetric Synthesis and Stereoselective Reactions
© Georg Thieme Verlag Stuttgart ˙ New York

Asymmetric Hydrogenation of Cyclic N-Alkyl Imines

Contributor(s): Mark Lautens, Patrick T. Franke
F. Chen, Z. Ding, J. Qin, T. Wang, Y. He, Q.-H. Fan*
Institute of Chemistry, Chinese Academy of Sciences, Beijing, P. R. of China
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Publication History

Publication Date:
20 September 2011 (online)

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Significance

A highly efficient protocol for the asymmetric hydrogenation of a range of cyclic N-alkyl imines was reported. The chiral cationic Ru-MsDPEN complexes afforded the products in excellent isolated yields and enantioselectivities (up to 98% ee). The reactions were typically carried out on a 0.2 mmol scale.