Subscribe to RSS
Please copy the URL and add it into your RSS Feed Reader.
https://www.thieme-connect.de/rss/thieme/en/10.1055-s-00000131.xml
Synfacts 2011(10): 1100-1100
DOI: 10.1055/s-0030-1261065
DOI: 10.1055/s-0030-1261065
Metal-Catalyzed Asymmetric Synthesis and Stereoselective Reactions
© Georg Thieme Verlag
Stuttgart ˙ New York
Cu-Catalyzed Asymmetric Propargylation of Ketones
K. R. Fandrick*, D. R. Fandrick, J. T. Reeves, J. Gao, S. L. Ma, W. J. Li, H. Lee, N. Grinberg, B. Lu, C. H. Senanayake
Boehringer Ingelheim Pharmaceuticals Inc., Ridgefield, USA
Further Information
Publication History
Publication Date:
20 September 2011 (online)
Significance
A simple Cu-BINAP catalyst system was developed which successfully promoted the highly enantioselective propargylation of ketones. The corresponding homopropargylic alcohols were obtained in good to high yields and enantioselectivities.