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Synfacts 2009(5): 0510-0510  
DOI: 10.1055/s-0029-1216599
Metal-Catalyzed Asymmetric Synthesis and Stereoselective Reactions
© Georg Thieme Verlag Stuttgart ˙ New York

Advancing Hydroaminoalkylations

Contributor(s): Mark Lautens, David A. Candito
J. A. Bexrud, P. Eisenberger, D. C. Leitch, P. R. Payne, L. L. Schafer*
University of British Columbia, Vancouver, Canada
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Publikationsdatum:
22. April 2009 (online)

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Significance

Hydroaminoalkylations provide an efficient route to α-substituted amines which are precursors to a number of industrially important compounds. The authors report the catalytic, ­intramolecular hydroaminoalkylation of amino­alkenes. Importantly, the alkylation is carried out in the absence of protecting groups and primary amines are employed as substrates, a feat which has not been previously reported.