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Synthesis 2025; 57(06): 1223-1229
DOI: 10.1055/a-2502-7704
DOI: 10.1055/a-2502-7704
paper
Scandium(III)-Catalyzed N-Alkylation of Carbazoles with Alcohols
This research was supported by Zhejiang Provincial Natural Science Foundation of China (Grant No. LY23B040001) and Programs Supported by Ningbo Natural Science Foundation (Grant No. 202003N4009).
Abstract
A general and efficient protocol has been developed for the N-alkylation of carbazoles with benzylic alcohols via scandium-catalyzed reaction. This transformation proceeds smoothly under an air atmosphere and features simple reaction conditions and wide substrate scope, which deliver a variety of N-alkylated carbazoles with up to 99% yields and broad functional group compatibilities.
Supporting Information
- Supporting information for this article is available online at https://doi.org/10.1055/a-2502-7704.
- Supporting Information
Publication History
Received: 09 October 2024
Accepted after revision: 15 December 2024
Accepted Manuscript online:
15 December 2024
Article published online:
22 January 2025
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