Gold(I)-Catalyzed Intramolecular C(sp3)–H Bond Functionalization

Dedicated to Prof. Carreira on the occasion of his 60^th birthday

Abstract

The merger of two of the most rapidly growing fields in catalysis, namely gold-catalysis and C–H activation/functionalization has resulted in major breakthroughs, affording unprecedented transformations. This review covers the most relevant contributions in this field during the last 10 years, restricted to the intramolecular functionalization of C(sp³)–H bonds.

1 Introduction

2 Carbene/Vinylidene Insertion

3 [1,5]-H Shift

4 Gold-Stabilized Vinyl Cation Mediated

5 Summary and Outlook

Key words

gold-catalysis - C–H functionalization - cyclization - carbene insertion - [1,5]-hydride shift - vinyl cation

Publication History

Received: 17 July 2024

Accepted after revision: 16 August 2024

Accepted Manuscript online:
16 August 2024

Article published online:
30 September 2024

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