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Synthesis 2022; 54(11): 2574-2584
DOI: 10.1055/a-1744-4566
DOI: 10.1055/a-1744-4566
feature
p-Quinol Ethers and p-Quinone Monoacetals as Arylation and Oxidation Reagents: Tandem N-Arylation and α-Functionalization of Pyrrolidine via Redox-Neutral Three-Component Reaction
Financial support from Scientific Research Innovation Project for Postgraduates of Jiangsu province (SJCX20_0361) and Nanjing Tech University is acknowledged.
Abstract
The value of functional pyrrolidines in the fields of biology, pharmacology, catalysis, and natural product synthesis stimulates an intensive interest in developing new synthetic methods for this class of compounds, and direct functionalization of the simple pyrrolidine represents an attractive and effective approach. Herein, a metal-free protocol for direct N-arylation and α-functionalization of pyrrolidine via redox-neutral three-component reactions is reported, in which p-quinol ethers or p-quinone monoacetals serve as the arylation components and the formal oxidants for α-functionalization of pyrrolidine.
Supporting Information
- Supporting information for this article is available online at https://doi.org/10.1055/a-1744-4566.
- Supporting Information
Publication History
Received: 27 December 2021
Accepted after revision: 18 January 2022
Accepted Manuscript online:
18 January 2022
Article published online:
08 March 2022
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