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Synlett 2003(15): 2305-2308
DOI: 10.1055/s-2003-42122
DOI: 10.1055/s-2003-42122
LETTER
© Georg Thieme Verlag Stuttgart · New York
Domino Palladium(II)-Mediated Rearrangement-Oxidative Cyclization of β-Aminocyclopropanols
Weitere Informationen
Received
9 September 2003
Publikationsdatum:
07. November 2003 (online)
Publikationsverlauf
Publikationsdatum:
07. November 2003 (online)
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Abstract
β-Aminocyclopropanols were transformed, in a domino process catalyzed by Pd(II) salts, into the corresponding 2,3-dihydro-1H-pyridin-4-ones. Conversely the use of a Pd(0) derivative, Pd(dba)2, afforded the corresponding tetrahydropyrid-4-ones. The saturated derivatives were also obtained, in better yields, using Pd(II) and Cu(OAc)2 as stoichiometric oxidant.
Key words
domino reactions - palladium - Wacker reactions - heterocycles - catalysis
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