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Synfacts 2011(12): 1324-1324
DOI: 10.1055/s-0031-1289334
DOI: 10.1055/s-0031-1289334
Metal-Catalyzed Asymmetric Synthesis and Stereoselective Reactions
© Georg Thieme Verlag
Stuttgart ˙ New York
Palladium-Catalyzed Enantioselective α-Arylation
Z. Huang, Z. Liu, J. Zhou*
Nanyang Technological University, Singapore
Further Information
Publication History
Publication Date:
18 November 2011 (online)
Significance
Palladium-catalyzed enantioselective α-arylation to form tertiary stereocenters was achieved. The formation of tertiary α-stereocenters is in certain respects more difficult than that of quaternary centers as the tertiary products are enolizable. This reaction allows efficient synthesis of the members of the anti-inflammatory profen drug family, such as ibuprofen and ketoprofen, with high yield and enantioselectivity.