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Journal of Pediatric Neurology 2010; 08(03): 299-310
DOI: 10.3233/JPN-2010-0407
Review Article
Georg Thieme Verlag KG Stuttgart – New York

Stroke in sickle cell disease

Fatema J. Serajee
a   Carman and Ann Adams Department of Pediatrics, Wayne State University, Detroit, MI, USA
,
Sharada A. Sarnaik
a   Carman and Ann Adams Department of Pediatrics, Wayne State University, Detroit, MI, USA
,
Deniz Altinok
b   Department of Radiology, Wayne State University, Detroit, MI, USA
,
A.H.M. Mahbubul Huq
a   Carman and Ann Adams Department of Pediatrics, Wayne State University, Detroit, MI, USA
c   Department of Neurology, Wayne State University, Detroit, MI, USA
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Publikationsverlauf

26. Juli 2009

02. September 2009

Publikationsdatum:
30. Juli 2015 (online)

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Abstract

Sickle cell disease (SCD) is the second commonest cause of stroke in the pediatric population. Cerebrovascular complications in SCD may involve large or small vessels and present as large infarctions, intracranial or subarachnoid hemorrhage, moyamoya disease or silent infarcts. Predictors of stroke in SCD include high blood flow velocity on transcranial Doppler, low hemoglobin value, absence of alpha-thalassemia, high white cell count, hypertension, silent brain infarction, and a history of chest crisis. Regular blood transfusions are used for primary and secondary prevention of stroke in SCD. Other management strategies include stem cell transplantation,

Keywords

Sickle cell disease - stroke