Download PDF
Thromb Haemost 2009; 101(01): 212-214
DOI: 10.1160/TH08-07-0478
Letters to the Editor
Schattauer GmbH

Haplotypic or genotypic combinations of three protein Z polymorphisms influence protein Z plasma level

Véronique Le Cam-Duchez
1   Unit of Vascular Haemostasis, Rouen University Hospital, Rouen, France
2   EA3829 (Research Group MERCI), Institute for Biomedical Research, University of Rouen, Rouen, France
,
Virginie Barbay
1   Unit of Vascular Haemostasis, Rouen University Hospital, Rouen, France
,
Claire Bal dit Sollier
3   Haematology Laboratory, Lariboisière University Hospital, Paris, France
,
Ludovic Drouet
3   Haematology Laboratory, Lariboisière University Hospital, Paris, France
,
Mathieu Coudert
4   APHP, PitiéSalpêtrière Charles-Foix Clinical Research Unit, Paris, France
5   UPMC Univ Paris 06, EA 3974, Modelling in Clinical Research, Paris, France
,
Claudine Soria
2   EA3829 (Research Group MERCI), Institute for Biomedical Research, University of Rouen, Rouen, France
3   Haematology Laboratory, Lariboisière University Hospital, Paris, France
,
Jeanne-Yvonne Borg
1   Unit of Vascular Haemostasis, Rouen University Hospital, Rouen, France
2   EA3829 (Research Group MERCI), Institute for Biomedical Research, University of Rouen, Rouen, France
› Author Affiliations
Further Information

Publication History

Received: 24 July 2008

Accepted after major revision: 08 October 2008

Publication Date:
23 November 2017 (online)

    Permissions and Reprints

 

 

  • References

  • 1 Tabatabai A, Fiehler R, Broze Jr. GJ. Protein Z circulates in plasma in a complex with protein Z-dependent protease inhibitor. Thromb Haemost 2001; 85: 655-660.
    Article in Thieme ConnectPubMedGoogle Scholar
  • 2 Cesari F, Fatini C, Sticchi E. et al. Protein Z gene polymorphisms (intron F 79 G>A; –13 A>G) are not associated with acute coronary syndromes. Thromb Haemost 2006; 96: 98-99.
    Article in Thieme ConnectPubMedGoogle Scholar
  • 3 Heeb MJ, Fisher M, Paganini-Hill A. Association of low protein Z levels with ischemic stroke in young women. Thromb Haemost 2007; 97: 495-496.
    Article in Thieme ConnectPubMedGoogle Scholar
  • 4 Sofi F, Cesari F, Pratesi G. et al. Low protein Z levels in patients with peripheral arterial disease. Thromb Haemost 2007; 98: 1114-1117.
    Article in Thieme ConnectPubMedGoogle Scholar
  • 5 Rice GI, Futers TS, Grant PJ. Identification of novel polymorphisms within the protein Z gene, haplotype distribution and linkage analysis. Thromb Haemost 2001; 85: 1123-1124.
    Article in Thieme ConnectPubMedGoogle Scholar
  • 6 Santacroce R, Cappucci F, Di Perna P. et al. Protein Z gene polymorphisms are associated with protein Z plasma levels. J Thromb Haemost 2004; 02: 1197-1199.
    CrossrefPubMedGoogle Scholar
  • 7 Staton J, Sayer M, Hankey GJ. et al. Protein Z gene polymorphisms, protein Z concentrations, and ischemic stroke. Stroke 2005; 36: 1123-1127.
    CrossrefPubMedGoogle Scholar
  • 8 Mazoyer E, Ripoll L, Gueguen R. et al. Environmental and genetic influences on fibrinogen level differently evidenced according to the technique of fibrinogen measurement: FITE NAT multicenter study. Thromb Haemost. 2001 Suppl July 2001: Abstract P2197.
    PubMedGoogle Scholar
  • 9 Lichy C, Kropp S, Dong-Si T. et al. A common polymorphism of the protein Z gene is associated with protein Z plasma levels and with risk of cerebral ischemia in the young. Stroke 2004; 35: 40-45.
    PubMedGoogle Scholar
  • 10 Le Cam-Duchez V, Bagan-Triquenot A, Barbay V. et al. The G79A polymorphism of protein Z gene is an independant risk factor for cerebral venous thrombosis. J Neurol. 2008 in press.
    PubMedGoogle Scholar
  • 11 Vasse M, Guegan-Massardier E, Borg JY. et al. Frequency of protein Z deficiency in patients with ischaemic stroke. Lancet 2001; 357: 933-934.
    CrossrefPubMedGoogle Scholar
  • 12 Kemkes-Matthes B, Matthes KJ. Protein Z deficiency: a new cause of bleeding tendency. Thromb Res 1995; 79: 49-55.
    CrossrefPubMedGoogle Scholar
  • 13 Miletich JP, Broze GJ. Jr. Human plasma protein Z antigen: range in normal subjects and effect of warfarin therapy. Blood 1987; 69: 1580-1586.
    PubMedGoogle Scholar
  • 14 Ravi S, Mauron T, Lammle B. et al. Protein Z in healthy human individuals and in patients with a bleeding tendency. Br J Haematol 1998; 102: 1219-1223.
    CrossrefPubMedGoogle Scholar
  • 15 Santacroce R, Sarno M, Cappucci F. et al. Low protein Z levels and risk of occurrence of deep vein thrombosis. J Thromb Haemost 2006; 04: 2417-2422.
    CrossrefPubMedGoogle Scholar
  • 16 Lichy C, Dong-Si T, Reuner K. et al. Risk of cerebral venous thrombosis and novel gene polymorphisms of the coagulation and fibrinolytic systems. J Neurol 2006; 253: 316-320.
    CrossrefPubMedGoogle Scholar