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Thromb Haemost 2007; 98(05): 1150-1152
DOI: 10.1160/TH07-03-0228
Letters to the Editor
Schattauer GmbH

Protease-activated receptor (PAR)1-mediated anti-apoptotic effect of activated protein C on glutamate excitotoxicity in hippocampal neurons

Lubov R. Gorbacheva
1   Department of Human and Animal Physiology, The Lomonosov Moscow State University, Moscow, Russia
,
Tatyana P. Storozhevykh
2   The Scientific Centre for Children`s Health, RAMS, Moscow, Russia
,
Vsevolod G. Pinelis
2   The Scientific Centre for Children`s Health, RAMS, Moscow, Russia
,
Shin'ichi Ishiwata
3   Advanced Research Institute for Science and Engineering, Waseda University, Tokyo, Japan
,
Svetlana M. Strukova
1   Department of Human and Animal Physiology, The Lomonosov Moscow State University, Moscow, Russia
› Author Affiliations Financial support:This work was partly sponsored by the Russian Foundation for Basic Research (project No. 05–04–49481).
Further Information

Publication History

Received 27 March 2007

Accepted after resubmission 24 August 2007

Publication Date:
30 November 2017 (online)

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  • References

  • 1 Strukova S, Gorbacheva L, Storozhevykh T. et al. Factor Xa protects cultured hippocampal neurons from glutamate toxicity. J Thromb Haemost 2006; 4: 1409-1410.
    CrossrefPubMedGoogle Scholar
  • 2 Gorbacheva LR, Storozhevykh TP, Pinelis VG. et al. Modulation of hippocampal neuron survival by thrombin and factor Xa. Biochemistry (Moscow) 2006; 71: 1082-1089.
    PubMedGoogle Scholar
  • 3 Esmon CT. Inflammation and the activated protein C anticoagulant pathway. Semin Thromb Hemost 2006; 32 (Suppl. 01) 49-60.
    Article in Thieme ConnectPubMedGoogle Scholar
  • 4 Guo H, Liu D, Gelbard H. et al. Activated protein C prevents neuronal apoptosis via protease activated receptors 1 and 3. Neuron 2004; 41: 563-572.
    CrossrefPubMedGoogle Scholar
  • 5 Yamauchi T, Sakurai M, Abe K. et al. Neuroprotective effects of activated protein C through induction of insulin-like growth factor-1 (IGF-1), IGF-1 receptor, and its downstream signal phosphorylated serine-treonine kinase after spinal cord ischemia in rabbits. Stroke 2006; 37: 1081-1086.
    CrossrefPubMedGoogle Scholar
  • 6 Cheng T, Petraglia AL, Li Z. et al. Activated protein C inhibits tissue plasminogen activator-induced brain hemorrhage. Nat Med 2006; 12: 1278-1285.
    CrossrefPubMedGoogle Scholar
  • 7 Choi DW, Rothman SM. The role of glutamate neurotoxicity in hypoxic-ischemic neuronal death. Annu Rev Neurosci 1990; 13: 171-182.
    CrossrefPubMedGoogle Scholar
  • 8 Miyata Y. Hsp90 inhibitor geldanamycin and its derivatives as novel cancer chemotherapeutic agents. Curr Pharm Des 2005; 11: 1131-1138.
    CrossrefPubMedGoogle Scholar
  • 9 Pai KS, Cunningham DD. Geldanamycin specifically modulates thrombin-mediated morphological changes in mouse neuroblasts. J Neurochem 2002; 80: 715-718.
    CrossrefPubMedGoogle Scholar
  • 10 Griffin JH, Fernandez JA, Liu D. et al. Activated protein C and ischemic stroke. Crit Care Med 2004; 32: S247-S253.
    CrossrefPubMedGoogle Scholar