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Synfacts 2008(8): 0837-0837  
DOI: 10.1055/s-2008-1078555
Metal-Catalyzed Asymmetric Synthesis and Stereoselective Reactions
© Georg Thieme Verlag Stuttgart ˙ New York

Heterobimetallic Complexes Catalyzed Double Diastereoselective Nitroaldol Reactions

Contributor(s): Hisashi Yamamoto, Cheol Hong Cheon
Y. Sohtome, Y. Kato, S. Handa, N. Aoyama, K. Nagawa, S. Matsunaga, M. Shibasaki*
The University of Tokyo, Japan
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Publication History

Publication Date:
23 July 2008 (online)

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Significance

The authors describe the stereodivergent construction of three contiguous stereocenters in catalytic double diastereoselective nitro­aldol reations of α-chiral aldehydes with nitro­aldehyde dimethylacetal using two types of het­erobimetallic catalysts. It is interesting that the facial selectivity of α-chiral aldehydes in the nitroaldol reactions was controlled by changing the chiral catalysts.