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Synfacts 2008(10): 1076-1076  
DOI: 10.1055/s-2008-1078138
Metal-Catalyzed Asymmetric Synthesis and Stereoselective Reactions
© Georg Thieme Verlag Stuttgart ˙ New York

Sulfonyldiamine-Cu Complex Catalyzed Asymmetric Henry Reaction

Contributor(s): Hisashi Yamamoto, Cheol Hong Cheon
T. Arai*, R. Takashita, Y. Endo, M. Watanabe, A. Yanagisawa
Chiba University, Japan
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Publication History

Publication Date:
22 September 2008 (online)

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Significance

The authors report a catalytic asymmetric Henry reaction with a sulfonyldiamine-CuCl complex. A series of chiral sulfonyldiamine ligands were readily synthesized in two steps from commercially available chiral 1,2-diamines. This catalyst system provided β-nitro alcohol adducts with high syn selectivity and excellent enantioselectivity.