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Synfacts 2008(10): 1068-1068  
DOI: 10.1055/s-2008-1078123
Metal-Catalyzed Asymmetric Synthesis and Stereoselective Reactions
© Georg Thieme Verlag Stuttgart ˙ New York

Titanium-Mediated Catalytic Enantioselective Ketone Arylation

Contributor(s): Mark Lautens, Praew Thansandote
C.-A. Chen, K.-H. Wu, H.-M. Gau*
National Chung Hsing University, Taichung, Taiwan, P. R. of China
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Publication History

Publication Date:
22 September 2008 (online)

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Significance

A new methodology for the asymmetric aryl addition of ketones by AlAr3(THF) is described. A stoichiometric amount of Ti(IV) is required, although a catalytic amount of ligand is sufficient. For AlAr3(THF) syntheses see: K.-H. Wu, H.-M. Gau J. Am. Chem. Soc. 2006, 128, 14808. For ligand synthesis see: C. García, L. K. LaRochelle, P. J. Walsh J. Am. Chem. Soc. 2002, 124, 10970.