Download PDF
Synfacts 2008(9): 0949-0949  
DOI: 10.1055/s-2008-1078010
Metal-Catalyzed Asymmetric Synthesis and Stereoselective Reactions
© Georg Thieme Verlag Stuttgart ˙ New York

An Improved Lanthanum Catalyst System for Asymmetric Amination

Contributor(s): Hisashi Yamamoto, Pingfan Li
T. Mashiko, N. Kumagai*, M. Shibasaki*
The University of Tokyo, Japan
Further Information

Publication History

Publication Date:
22 August 2008 (online)

    Permissions and Reprints

Significance

Catalytic asymmetric amination using azo compounds as nitrogen source is becoming a versatile method for the preparation of various useful building blocks. This paper described the development of a practical protocol based on further optimization of a previously reported lanthanum catalyst system. A one-hundred gram scale experiment nicely showcased the robust nature of this reaction.