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Synfacts 2008(7): 0721-0721  
DOI: 10.1055/s-2008-1077851
Metal-Catalyzed Asymmetric Synthesis and Stereoselective Reactions
© Georg Thieme Verlag Stuttgart · New York

Adaptive Supramolecular Ligands in Rhodium-Catalyzed Hydrogenation

Contributor(s): Hisashi Yamamoto, Pingfan Li
F. W. Patureau, M. Kuil, A. J. Sandee, J. N. H. Reek*
University of Amsterdam and BASF Nederland B.V. Catalysts, De Meern, The Netherlands
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Publication History

Publication Date:
20 June 2008 (online)

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Significance

The designed METAMORPhos ligand, an adaptive supramolecular building block, which can dynamically adapt various tautomeric forms and give rise to a unique mechanism in the asymmetric hydrogenation reaction, is described in this paper. Good enantioselectivity and turn-over frequency is achieved through the use of such a hydrogen-bound hetero bis-ligated rhodium complex.