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Dtsch Med Wochenschr 2008; 133(18): 954-958
DOI: 10.1055/s-2008-1075673
DOI: 10.1055/s-2008-1075673
Prinzip & Perspektive
Nephrologie, Molekularbiologie
© Georg Thieme Verlag KG Stuttgart · New York
Molekulare Pathogenese der Proteinurie
Molecular pathogenesis of proteinuriaFurther Information
Publication History
eingereicht: 7.8.2007
akzeptiert: 28.1.2008
Publication Date:
23 April 2008 (online)
Schlüsselwörter
Proteinurie - nephrotisches Syndrom - Podozyt - Nephrin
Key words
proteinuria - nephrotic syndrome - podocyte - nephrin
Literatur
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- 2 Huber T B, Benzing T. The slit diaphragm: a signaling platform to regulate podocyte function. Curr Opin Nephrol Hypertens. 2005; 14 211-216
- 3 Huber T B, Hartleben B, Kim J. et al . Nephrin and CD2AP associate with phosphoinositide 3-OH kinase and stimulate AKT-dependent signaling. Mol Cell Biol. 2003; 23 4917-4928
- 4 Huber T B, Kwoh C, Wu H. et al . Bigenic mouse models of focal segmental glomerulosclerosis involving pairwise interaction of CD2AP, Fyn, and synaptopodin. J Clin Invest. 2006; 116 1337-1345
- 5 Huber T B, Schermer B, Benzing T. Podocin organizes ion channel-lipid supercomplexes: implications for mechanosensation at the slit diaphragm. Nephron Exp Nephrol. 2007; 106 e27-e31
- 6 Huber T B, Schermer B, Muller R U. et al . Podocin and MEC-2 bind cholesterol to regulate the activity of associated ion channels. Proc Natl Acad Sci U S A. 2006; 103 17079-17086
- 7 Huber T B, Schmidts M, Gerke P. et al . The carboxyl terminus of Neph family members binds to the PDZ domain protein zonula occludens-1. J Biol Chem. 2003; 278 13417-13421
- 8 Huber T B, Simons M, Hartleben B. et al . Molecular basis of the functional podocin-nephrin complex: mutations in the NPHS2 gene disrupt nephrin targeting to lipid raft microdomains. Hum Mol Genet. 2003; 12 3397-3405
- 9 Kestila M, Lenkkeri U, Mannikko M. et al . Positionally cloned gene for a novel glomerular protein - nephrin - is mutated in congenital nephrotic syndrome. Mol Cell. 1998; 1 575-582
- 10 Nagata M, Scharer K, Kriz W. Glomerular damage after uninephrectomy in young rats. I. Hypertrophy and distortion of capillary architecture. Kidney Int. 1992; 42 136-147
- 11 Pavenstadt H, Kriz W, Kretzler M. Cell biology of the glomerular podocyte. Physiol Rev. 2003; 83 253-307
- 12 Pollak M R. The genetic basis of FSGS and steroid-resistant nephrosis. Semin Nephrol. 2003; 23 141-146
- 13 Schlondorff J S, Pollak M R. TRPC6 in glomerular health and disease: what we know and what we believe. Semin Cell Dev Biol. 2006; 17 667-674
- 14 Smithies O. Why the kidney glomerulus does not clog: a gel permeation/diffusion hypothesis of renal function. Proc Natl Acad Sci U S A. 2003; 100 4108-4113
- 15 Wartiovaara J, Ofverstedt L G, Khoshnoodi J. et al . Nephrin strands contribute to a porous slit diaphragm scaffold as revealed by electron tomography. J Clin Invest. 2004; 114 1475-1483
- 16 Wiggins R C. The spectrum of podocytopathies: a unifying view of glomerular diseases. Kidney Int. 2007; 71 1205-1214
PD Dr. med. Tobias B. Huber
Medizinische Klinik IV, Nephrologie, Universitätsklinik Freiburg
Hugstetterstraße 55
79106 Freiburg
Phone: 0761/270-3559
Fax: 0761/270-6324
Email: tobias.huber@uniklinik-freiburg.de