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Synfacts 2008(5): 0446-0446  
DOI: 10.1055/s-2008-1072705
Synthesis of Natural Products and Potential Drugs
© Georg Thieme Verlag Stuttgart · New York

Synthesis of Pasteurestin A and B

Contributor(s): Philip Kocienski, Indu Dager
M. Kögl, L. Brecker, R. Warrass, J. Mulzer*
Universität Wien, Austria and Intervet Innovation GmbH, Schwabenheim, Germany
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Publication History

Publication Date:
23 April 2008 (online)

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Significance

Pasteurestins A and B show selective antibacterial activities against some strains of Pasteurella multocida and also against Mann­heimia haemolytica, a pathogen for bovine respiratory disease. The synthesis is based on the diastereo­selective Vollhardt [2+2+2] cycloaddition of enediynes E and J.