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Synfacts 2008(5): 0447-0447  
DOI: 10.1055/s-2008-1072703
Synthesis of Natural Products and Potential Drugs
© Georg Thieme Verlag Stuttgart · New York

Synthesis of (-)-Okilactomycin

Contributor(s): Philip Kocienski, Arndt W. Schmidt
A. B. Smith, III*, K. Basu, T. Bosanac
University of Pennsylvania, Philadelphia, USA
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Publication History

Publication Date:
23 April 2008 (online)

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Significance

(+)-Okilactomycin was isolated from a Streptomyces strain. The structure was assigned based on spectroscopic methods; however, the absolute configuration remained elusive. For the first time an enantioselective synthesis of okilactomycin has been achieved, albeit yielding the non-natural enantiomer.