Intraluminal Oxybutynin Chloride Inhibits Contraction of Isolated Ileal Segment in the Dog

Summary:

Intraluminal administration of oxybutynin chloride (OC) was evaluated in the prevention of spontaneous bowel contraction in the dog. Two ileal segments of 10 cm were isolated and anastomosed to the skin in 8 dogs. One month later, 10 ml of OC (5 mg/ml) were instilled into one of the ileal segments (OIS) and the same amount of saline into the other (SIS). The contraction pressure of OIS decreased significantly in 10 min after OC instillation. The contraction pressure of SIS did not change significantly. The serum concentration of OC was not detectable before 60 min after the administration. Our data showed that the contraction of OIS was directly inhibited by OC because contraction of SIS was not influenced and because serum OC concentration was not elevated. Therefore, intrapouch administration of OC may be effective to lessen incontinence by preventing contraction of the pouch without gastrointestinal side effects.

Key words:

Oxybutynin - Bowel - Urinary diversion