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Neuropediatrics 1988; 19(3): 158-161
DOI: 10.1055/s-2008-1052421
DOI: 10.1055/s-2008-1052421
Evaluation of the Cytotoxicity of Sodium Valproate on Primary Cultured Rat Hepatocytes
Further Information
Publication History
Publication Date:
19 March 2008 (online)
Abstract
Primary cultured rat hepatocytes were used to study the cytotoxicity of sodium valproate (VPA). Cytotoxicity was monitored by measurement of leakage of intracellular enzymes into the culture medium: lactate dehydrogenase (LDH), glutamate oxaloacetate transaminase (GOT), glutamate pyruvate transaminase (GPT). The effects of D,L-carnitine and albumin administration on the cytotoxicity were evaluated.
LDH leakage rose with an increasing dose of VPA. Administrations of D,L-carnitine and albumin reduced VPA hepatotoxicity. Our data suggest that VPA-induced hepatotoxicity is dose-related and may be modulated by serum carnitine and albumin levels.
Key words
Hepatotoxicity - LDH - Valproate - Carnitine - Albumin - Rat