Dtsch Med Wochenschr 2008; 133(8): 367-369
DOI: 10.1055/s-2008-1046721
Kommentar | Commentary
Infektiologie, Gastroenterologie
© Georg Thieme Verlag KG Stuttgart · New York

Probiotika - evidenzbasierte Medizin oder alternativmedizinischer Hokuspokus?

Probiotics - evidence-based medicine or simply hocus-pocus?J. Huebner1 , C. Franz2 , M. Kopp3
  • 1Infektiologie, Innere Medizin, Universitätsklinikum Freiburg
  • 2Institut für Hygiene und Toxikologie, Bundesforschungsanstalt für Ernährung und Lebensmittel, Karlsruhe
  • 3Zentrum für Kinderheilkunde und Jugendmedizin, Universitätsklinikum Freiburg
Further Information

Publication History

eingereicht: 16.10.2007

akzeptiert: 21.1.2008

Publication Date:
13 February 2008 (online)

Literatur

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  • 2 Brouwer M L, Wolt-Plompen S A, Dubois A E, van der Heide S, Jansen D F, Hoijer M A, Kauffman H F, Duiverman E J. No effects of probiotics on atopic dermatitis in infancy: a randomized placebo-controlled trial.  Clin Exp Allergy. 2006;  36 899-906
  • 3 Floch M H, Madsen K K, Jenkins D J, Guandalini S, Katz J A, Onderdonk A, Walker W A, Fedorak R N, Camilleri M. Recommendations for probiotic use.  J Clin Gastroenterol. 2006;  40 275-278
  • 4 Gruber C, Wendt M, Sulser C, Lau S, Kulig M, Wahn U, Werfel T, Niggemann B. Randomized, placebo-controlled trial of Lactobacillus rhamnosus GG as treatment of atopic dermatitis in infancy.  Allergy. 2007;  62 1270-1276
  • 5 Helin T, Haahtela S, Haahtela T. No effect of oral treatment with an intestinal bacterial strain, Lactobacillus rhamnosus (ATCC 53103), on birch-pollen allergy: a placebo-controlled double-blind study.  Allergy. 2002;  57 243-246
  • 6 Huang J S, Bousvaros A, Lee J W, Diaz A, Davidson E J. Efficacy of probiotic use in acute diarrhea in children: a meta-analysis.  Dig Dis Sci. 2002;  47 2625-2634
  • 7 Huys G, Vancanneyt M, D’Haene K, Vankerckhoven V, Goossens H, Swings J. Accuracy of species identity of commercial bacterial cultures intended for probiotic or nutritional use.  Res Microbiol. 2006;  157 803-810
  • 8 Kalliomaki M, Salminen S, Arvilommi H, Kero P, Koskinen P, Isolauri E. Probiotics in primary prevention of atopic disease: a randomised placebo-controlled trial.  Lancet. 2001;  357 1076-1079
  • 9 Kalliomaki M, Salminen S, Poussa T, Arvilommi H, Isolauri E. Probiotics and prevention of atopic disease: 4-year follow-up of a randomised placebo-controlled trial.  Lancet. 2003;  361 1869-1871
  • 10 Kopp M, Hennemuth I, Dietschek A, Goldstein M, Ihorst G, Heinzmann A, Urbanek R. A randomized, double-blind, placebo-controlled trial of probiotics for primary prevention: No clinical or immunological effects of Lactobacillus GG supplementation. Pediatrics in press
  • 11 Kruis W, Fric P, Pokrotnieks J, Lukas M, Fixa B, Kascak M, Kamm M A, Weismueller J, Beglinger C, Stolte M, Wolff C, Schulze J. Maintaining remission of ulcerative colitis with the probiotic Escherichia coli Nissle 1917 is as effective as with standard mesalazine.  Gut. 2004;  53 1617-1623
  • 12 McFarland L V. Meta-analysis of probiotics for the prevention of antibiotic associated diarrhea and the treatment of Clostridium difficile disease.  Am J Gastroenterol. 2006;  101 812-822
  • 13 McFarland L V. Meta-analysis of probiotics for the prevention of traveler’s diarrhea.  Travel Med Infect Dis. 2007;  5 97-105
  • 14 Salminen M K, Tynkkynen S, Rautelin H, Saxelin M, Vaara M, Ruutu P, Sarna S, Valtonen V, Jarvinen A. Lactobacillus bacteremia during a rapid increase in probiotic use of Lactobacillus rhamnosus GG in Finland.  Clin Infect Dis. 2002;  35 1155-1160
  • 15 Taylor A L, Dunstan J A, Prescott S L. Probiotic supplementation for the first 6 months of life fails to reduce the risk of atopic dermatitis and increases the risk of allergen sensitization in high-risk children: a randomized controlled trial.  J Allergy Clin Immunol. 2007;  119 184-191
  • 16 Van Niel C W, Feudtner C, Garrison M M, Christakis D A. Lactobacillus therapy for acute infectious diarrhea in children: a meta-analysis.  Pediatrics. 2002;  109 678-684
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Prof. Dr. med. Johannes Huebner

Infektiologie, Innere Medizin II, Universitätsklinikum Freiburg

Hugstetter Str. 55

79106 Freiburg

Phone: 0761/270-1828

Fax: 0761/270-1820

Email: johannes.huebner@uniklinik-freiburg.de

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