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Synfacts 2008(3): 0293-0293  
DOI: 10.1055/s-2008-1042740
Metal-Mediated Synthesis
© Georg Thieme Verlag Stuttgart · New York

Reverse Prenylation, Crotylation and Allylation of Alcohols and Aldehydes via Transfer Hydrogenation

Contributor(s): Paul Knochel, Tobias Thaler
J. F. Bower, E. Skucas, R. L. Patman, M. J. Krische*
University of Texas at Austin, USA
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Publication History

Publication Date:
21 February 2008 (online)

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Significance

A new method for allylation, crotyl­ation, and reverse prenylation by Ir-catalyzed transfer hydrogenation is reported for both alcohols and aldehydes. The hydride is hereby directly provided by the respective alcohols. When aldehydes are used in this reaction, i-PrOH serves as hydride donor. Similar yields are achieved with both variants.