Subscribe to RSS
Please copy the URL and add it into your RSS Feed Reader.
https://www.thieme-connect.de/rss/thieme/en/10.1055-s-00000131.xml
Synfacts 2008(3): 0302-0302
DOI: 10.1055/s-2008-1042736
DOI: 10.1055/s-2008-1042736
Metal-Mediated Synthesis
© Georg Thieme Verlag Stuttgart · New York
Direct Aminoalkylation via Nickel-Catalyzed Negishi Cross-Coupling Reactions
L. Melzig, A. Gavryushin, P. Knochel*
Ludwig-Maximilians-Universität München, Germany
Further Information
Publication History
Publication Date:
21 February 2008 (online)
Significance
A new general method for the one-pot introduction of aminoalkyl groups via Negishi-type cross-coupling is reported. It was applied to the cross-coupling with both aryl and hetaryl halides and triflates furnishing the respective products with good to excellent yields. It is noteworthy that cross-coupling of tropanyl zinc reagents proceeds with 100% exo-selectivity. This is due to the stereospecific formation of the corresponding Grignard reagent.