Anthocleistenolide, A New Rearranged Nor-Secoiridoid Derivative from the Stem Bark of Anthocleista vogelii

Abstract

A new rearranged nor-secoiridoid, anthocleistenolide (1), along with the known 1-hydroxy-3,7-dimethoxyxanthone (2), 1-hydroxy-3,7,8-trimethoxyxanthone (3), 7α-hydroxysitosterol (4) and sitosterol 3-O-β-D-glucopyranoside (5), were isolated from the stem bark of Anthocleista vogelii. Their structures were elucidated on the basis of spectral studies and comparison with published data. Compounds 1 - 3 and 5 were evaluated for their antibacterial and antifungal activities. Relatively low anti-staphylococcal (MIC = 200 μg/mL against Staphylococcus aureus) and anti-enterococcal (MIC = 100 μg/mL against Enterococcus faecalis) activities were observed for 1, while compounds 2 and 3 were active against Candida parapsilosis (MIC = 200 μg/mL for 2 and 25 μg/mL for 3). Compound 5 was inactive against all the bacterial and fungal species used.

Key words

Anthocleista vogelii - Gentianaceae - nor-secoiridoid - anthocleistenolide - xanthones - antimycrobial activity

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