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Synfacts 2008(2): 0165-0165
DOI: 10.1055/s-2007-992449
DOI: 10.1055/s-2007-992449
Metal-Catalyzed Asymmetric Synthesis and Stereoselective Reactions
© Georg Thieme Verlag Stuttgart · New York
SimplePhos Monodentate Ligands: Synthesis and Applications
L. Palais, I. S. Mikhel, C. Bournaud, L. Micouin, C. A. Falciola, M. Vuagnoux-d’Augustin, S. Rosset, G. Bernardinelli, A. Alexakis*
Université de Genève, Switzerland and Université René Descartes, Paris, France
Further Information
Publication History
Publication Date:
23 January 2008 (online)
Significance
The Alexakis group describes a new class of monodentate phosphorous ligands termed SimplePhos. These modular ligands are based on bisarylaminophosphines instead of the more common phosphoramidite compounds. These ligands achieved similar or better enantioselectivities than their phosphoramidite counterparts in the copper-catalyzed conjugate addition reaction to cyclohexenones, desymmetrization of polycyclic hydrazines as well as allylic alkylation.